ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2012
The clinical value of single photon emission computed tomography myocardial perfusion imaging in cardiac risk stratification of very elderly patients (≥80 years) with suspected coronary artery disease.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
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- Blunted heart rate response during dipyridamole stress SPECT is associated with cardiovascular outcomes in an all-comers cohort.BMC cardiovascular disorders · 2026Article
- Re-evaluating stress testing paradigms in older adults.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Article
- Impact of cardiac size on diagnostic performance of single-photon emission computed tomography myocardial perfusion imaging: insights from the REgistry of Fast Myocardial Perfusion Imaging with NExt generation single-photon emission computed tomography.European heart journal. Cardiovascular Imaging · 2024Article
- Cardiovascular outcomes and mortality after abnormal myocardial perfusion scans in the elderly: a retrospective study at a tertiary care institution.Journal of geriatric cardiology : JGC · 2023Article
- Cardiovascular Biomarkers and Imaging in Older Adults: JACC Council Perspectives.Journal of the American College of Cardiology · 2020Review
- Risk Stratification of Cardiovascular Events in Very Elderly Patients with Known or Suspected Coronary Artery Disease Who Had Normal Single-photon Emission Computed Tomographic Myocardial Perfusion Imaging Findings.Internal medicine (Tokyo, Japan) · 2019Observational
- Association between abnormal myocardial scintigraphy findings and long-term outcomes for elderly patients 85 years or older: a retrospective cohort study.BMC cardiovascular disorders · 2019Article
- Adenosine stress myocardial perfusion imaging in octogenarians: Safety, tolerability, and long-term prognostic implications of hemodynamic response and SPECT-related variables.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Prognostic accuracy of myocardial perfusion imaging in octogenarians.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Prediction of 14-year cardiovascular outcomes by dobutamine stressJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Has anyone been listening? Post-SPECT MPI referral rates to catheterization.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Long-term prognostic implications of myocardial perfusion imaging in octogenarians: an all-comer, cohort study.European journal of nuclear medicine and molecular imaging · 2017Article
- Adenosine triphosphate stress myocardial perfusion imaging for risk stratification of patients aged 70 years and older with suspected coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Long-term prognostic value of myocardial perfusion imaging in octogenarians able to undergo treadmill exercise stress testing.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Myocardial perfusion imaging in very elderly patients with suspected coronary artery disease: never too late!Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of single photon emission computed tomography myocardial perfusion imaging (SPECT MPI) in cardiac evaluation of the very elderly patients is unclear. We investigated the clinical value of SPECT MPI in very elderly patients (≥80 years) with suspected coronary artery disease (CAD) as well as in comparison to younger patients. METHODS AND
resultsA retrospective analysis of prospectively collected data from 8,864 patients [1,093 patients ≥80 years (very elderly), 3,369 patients 65-79 years (elderly), and 4,402 patients 50-64 years (middle-aged)] with suspected CAD who underwent exercise and/or pharmacologic stress testing with SPECT MPI between 1996 and 2005 was performed. Clinical and SPECT MPI characteristics, cardiac event rates, early (≤60 days) cardiac catheterization and revascularization rates of very elderly patients were compared to that of younger patients. Mean follow-up for cardiac events (cardiac death or non-fatal myocardial infarction) was 1.9 ± 0.9 years. Very elderly patients with moderate to severely abnormal SSS had a significantly higher annualized cardiac event rate than those with mildly abnormal or normal study (9.6% vs 3.4% and 2.5% respectively, P < .001). Across all categories of SSS, very elderly patients had a significantly higher cardiac event rate as compared to younger patients (P < .001). Early cardiac catheterization and revascularization referrals in very elderly patients increased as a function of severity of ischemia on SPECT MPI (P < .001), although these referral rates were significantly lower in very elderly patients with mild to moderate and severe ischemia as compared to younger patients (P < .05).
conclusionsIn very elderly patients (≥80 years) with suspected CAD, SPECT MPI has prognostic and incremental value in the noninvasive cardiovascular assessment for risk stratification and may influence medical decisions.
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