ArticleThe Journal of trauma2011
Burn injury dampens erythroid cell production through reprioritizing bone marrow hematopoietic response.
Article in The Journal of trauma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Nucleated red blood cells as early indicators of sepsis in severe burns.Burns & trauma · 2026Article
- IL-1/MyD88-Dependent G-CSF and IL-6 Secretion Mediates Postburn Anemia.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Murine scald models characterize the role of neutrophils and neutrophil extracellular traps in severe burns.Frontiers in immunology · 2023Article
- M-CSF supports medullary erythropoiesis and erythroid iron demand following burn injury through its activity on homeostatic iron recycling.Scientific reports · 2022Article
- Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine Response.Frontiers in immunology · 2020Article
- Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A Shift in Myeloid Cell Phenotype via Down Regulation of Siglec-1 in Island Macrophages of Bone Marrow Is Associated With Decreased Late Erythroblasts Seen in Anemia of Critical Illness.Frontiers in medicine · 2019Article
- Terminal Maturation of Orthochromatic Erythroblasts Is Impaired in Burn Patients.Journal of burn care & research : official publication of the American Burn Association · 2018Article
- A Randomized Controlled Trial: Regenerative Effects, Efficacy and Safety of Erythropoietin in Burn and Scalding Injuries.Frontiers in pharmacology · 2018Article
- Thermal injury of the skin induces G-CSF-dependent attenuation of EPO-mediated STAT signaling and erythroid differentiation arrest in mice.Experimental hematology · 2017Article
- Discrete β-adrenergic mechanisms regulate early and late erythropoiesis in erythropoietin-resistant anemia.Surgery · 2017Article
- Myelo-erythroid commitment after burn injury is under β-adrenergic control via MafB regulation.American journal of physiology. Cell physiology · 2017Article
- Perturbed MafB/GATA1 axis after burn trauma bares the potential mechanism for immune suppression and anemia of critical illness.Journal of leukocyte biology · 2016Article
- Animal models in burn research.Cellular and molecular life sciences : CMLS · 2014Review
- G-CSF drives a posttraumatic immune program that protects the host from infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- History of burns: The past, present and the future.Burns & trauma · 2014Article
- A key role for lipoic acid synthesis during Plasmodium liver stage development.Cellular microbiology · 2013Article
- High MafB expression following burn augments monocyte commitment and inhibits DC differentiation in hemopoietic progenitors.Journal of leukocyte biology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAnemia in burn patients is due to surgical blood loss and anemia of critical illness. Because the commitment paradigm of common bone marrow progenitors dictates the production of erythroid, myeloid, and lymphoid cells, we hypothesized that skewed bone marrow lineage commitment decreases red cell production and causes anemia after a burn injury.
methodsAfter anesthesia, B(6)D(2)F(1) mice received a 15% total body surface area dorsal scald burn. The sham group did not receive scald burn. Femoral bone marrow was harvested on 2, 5, 7, 14, and 21 postburn days (PBD). Total bone marrow cells were labeled with specific antibodies to erythroid (CD71/Ter119), myeloid (CD11b), and lymphoid (CD19) lineages and analyzed by flow cytometry. To test whether erythropoietin (EPO) could increase red blood cell production, EPO was administered to sham and burn animals and their reticulocyte response was measured on PBD 2 and PBD 7.
resultsBurn injury reduced the erythroid cells of the bone marrow from 35% in sham to 17% by PBD 5 and remained at similar level until PBD 21. Myeloid cells, however, increased from 42% in sham to 60% on PBD 5 and 77% on PBD 21. Burn injury reduced reticulocyte counts on PBD 2 and PBD 7 indicating that the erythroid compartment is severely depleted. This depleted compartment, however, responded to EPO but was not sufficient to change red cell production.
conclusionBurn injury skews the bone marrow hematopoietic commitment away from erythroid and toward myeloid cells. Shrinkage of the erythroid compartment contributes to resistance to EPO and the anemia of critical illness.
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