ArticleGenome biology and evolution2011
A model for the effect of homologous recombination on microbial diversification.
Article in Genome biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Current Approaches for Genetic Manipulation ofBiotech (Basel (Switzerland)) · 2025Review
- Adaptations to nitrogen availability drive ecological divergence of chemosynthetic symbionts.PLoS genetics · 2024Article
- High speciation rate of niche specialists in hot springs.The ISME journal · 2023Article
- Global biogeography of chemosynthetic symbionts reveals both localized and globally distributed symbiont groups.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- An Update on Molecular Tools for Genetic Engineering of Actinomycetes-The Source of Important Antibiotics and Other Valuable Compounds.Antibiotics (Basel, Switzerland) · 2020Review
- Gene gain and loss push prokaryotes beyond the homologous recombination barrier and accelerate genome sequence divergence.Nature communications · 2019Article
- Comparative Analysis of the TwoFrontiers in microbiology · 2019Article
- Exclusivity offers a sound yet practical species criterion for bacteria despite abundant gene flow.BMC genomics · 2018Article
- Genomic Inference of Recombination-Mediated Evolution in Xanthomonas euvesicatoria and X. perforans.Applied and environmental microbiology · 2018Article
- Genomic divergence and cohesion in a species of pelagic freshwater bacteria.BMC genomics · 2017Article
- Article
- Speciation trajectories in recombining bacterial species.PLoS computational biology · 2017Article
- Contributions of ancestral inter-species recombination to the genetic diversity of extant Streptomyces lineages.The ISME journal · 2016Article
- Recombination produces coherent bacterial species clusters in both core and accessory genomes.Microbial genomics · 2015Article
- Inferring Speciation Processes from Patterns of Natural Variation in Microbial Genomes.Systematic biology · 2015Article
- Intraspecies comparison of Streptomyces pratensis genomes reveals high levels of recombination and gene conservation between strains of disparate geographic origin.BMC genomics · 2014Article
- Rapid forward-in-time simulation at the chromosome and genome level.BMC bioinformatics · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of homologous recombination (HR) on the evolution of microbial genomes remains contentious as competing hypotheses seek to explain the evolutionary dynamics of microbial species. Evidence for HR between microbial genomes is widespread, and this process has been proposed to act as a cohesive force that can constrain the diversification of microbial lineages. We seek to characterize the evolutionary dynamics of sympatric populations to explore the impact of HR on microbial speciation. We describe a simple equation for quantifying the cohesive effect of HR on microbial populations as a function of their nucleotide divergence, μ/ρ=πg10(-20 πg). The model was verified using a forward-time microbial population simulator that can explore the evolutionary dynamics of sympatric populations in nonoverlapping niche space. The model was also evaluated using multilocus sequence data from a range of microbial species, providing criteria for dividing them into either cohesively recombining or clonally diverging lineages. We conclude that models of microbial diversification that appear contradictory can be explained in a unified manner as the natural and predictable consequence of variation in a small number of population parameters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.