Evidence map›Paper›PMID 22071707›Full record

Trial reportThe American journal of clinical nutrition2011

Biomarker-calibrated dietary energy and protein intake associations with diabetes risk among postmenopausal women from the Women's Health Initiative.

Lesley F Tinker, Gloria E Sarto, Barbara V Howard, Ying Huang, Marian L Neuhouser, Yasmin Mossavar-Rahmani, Jeannette M Beasley, Karen L Margolis, Charles B Eaton, Lawrence S Phillips and 1 more

4 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 85 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 5 pooled it
6.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000611 phase3completednot on this map

Women's Health Initiative (WHI)

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)ConditionsBone Diseases, Breast Neoplasms, Cardiovascular Diseases, Colonic NeoplasmsArmshormone replacement therapy, estrogens, progestins, estrogen replacement therapy, diet, fat-restricted
NCT00787839 completednot on this map

Screening for Prediabetes and Early Diabetes in Primary Care

TypeobservationalSponsorUS Department of Veterans AffairsRan2009 to 2012Enrolled1,939ConditionsType 2 Diabetes Mellitus, Prediabetic StateArmsGlucose challenge test, Glucose tolerance test
NCT03627104 nacompletednot on this mapstarted 2018, after this paper: background citation

Effect of Dietary Protein and Energy Restriction in the Improvement of Insulin Resistance in Subjects With Obesity

TypeinterventionalSponsorInstituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranRan2018 to 2020Enrolled80ConditionsObesity, Insulin ResistanceArmsNormoprotein diet with animal protein, Normoprotein diet with vegetable protein, High-protein diet with animal protein, High-protein diet with vegetable protein
NCT06449170 naunknown statusnot on this mapstarted 2023, after this paper: background citation

BIAMEX: Discovery of Biomarkers of Intake of Highly Consumed Foods in Mexico by Untargeted Metabolomics

TypeinterventionalSponsorInstituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranRan2023 to 2024Enrolled12ConditionsNutrition, Healthy, Diet Habit, Diet, Healthy, Dietary ExposureArmsMango Ataulfo, Avocado Hass, Nopal, 3 corn tortilla, Guava
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 5 syntheses or guidelines pooled it, 122 citations in OpenAlex.

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  13. An exploratory study of respiratory quotient calibration and association with postmenopausal breast cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Lesley F TinkerFred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. ltinker@whi.org
Gloria E Sarto
Barbara V Howard
Ying Huang
Marian L Neuhouser
Yasmin Mossavar-Rahmani
Jeannette M Beasley
Karen L Margolis
Charles B Eaton
Lawrence S Phillips
Ross L Prentice
Fred Hutch Cancer Center · USEmory University · USGeorgetown University · USMemorial Hospital of Rhode Island · USRegions Hospital · USUniversity of Wisconsin–Madison · US

Funding

WEIGHT MGT &NUTRITION FOR PRE-/PERIMENOPAUSAL BREAST CANCER SURVIVORSM01RR012248 · NCRR · YESHIVA UNIVERSITY · PI CRANDALL, JILL P · 1997 to 2008
$18.4M
Nutrition and Physical Activity Assessment Study (NPAAS)R01CA119171 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian L Neuhouser · 2006 to 2026
$14.3M
Use of Biomarkers in Diagnosis, Prognosis, Risk Prediction and Early Detection ofP01CA053996 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HSU, LI · 1991 to 2015
$9.4M
Study of Latinos: Nutrition & Physical Activity Assessment Study (SOLNAS)R01HL095856 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MOSSAVAR-RAHMANI, YASMIN · 2010 to 2013
$3.1M
NCI NIH HHS CA119171NCI NIH HHS CA53996NCI NIH HHS R01 CA119171NCRR NIH HHS M01 RR012248NHLBI NIH HHS R01 HL095856
6 · The paper itself

Abstract

backgroundSelf-report of dietary energy and protein intakes has been shown to be systematically and differentially underreported.

objectiveWe assessed and compared the association of diabetes among postmenopausal women with biomarker-calibrated and uncalibrated dietary energy and protein intakes from food-frequency questionnaires (FFQs).

designThe analyses were performed for 74,155 participants of various race-ethnicities from the Women's Health Initiative. Uncalibrated and calibrated energy and protein intakes from FFQs were assessed for associations with incident diabetes by using HR estimates based on Cox regression.

resultsA 20% increment in uncalibrated energy consumption was associated with increased diabetes risk (HR) of 1.03 (95% CI: 1.01, 1.05), 2.41 (95% CI: 2.06, 2.82) with biomarker calibration, and 1.30 (95% CI: 0.96, 1.76) after adjustment for BMI. A 20% increment in uncalibrated protein (g/d) resulted in an HR of 1.05 (95% CI: 1.03, 1.07), 1.82 (95% CI: 1.56, 2.12) with calibration, and 1.16 (95% CI: 1.05, 1.28) with adjustment for BMI. A 20% increment in uncalibrated protein density (% of energy from protein) resulted in an HR of 1.13 (95% CI: 1.09, 1.17), 1.01 (95% CI: 0.75, 1.37) with calibration, and 1.19 (95% CI: 1.07, 1.32) with adjustment for BMI.

conclusionsHigher protein and total energy intakes (calibrated) appear to be associated with a substantially increased diabetes risk that may be mediated by an increase in body mass over time. Diet-disease associations without correction of self-reported measurement error should be viewed with caution. This trial is registered at clinicaltrials.gov as NCT00000611.

Indexed as

Body Mass IndexEnergy IntakeAgedAged, 80 and overBiomarkersCalibrationDiabetes MellitusDietary ProteinsDiet SurveysFemaleHumansMiddle AgedPostmenopauseProportional Hazards ModelsRisk FactorsSelf ReportBiomarkersDietary Proteins

Identifiers

PMID22071707
PMCPMC3252553
OpenAlexW1965378272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.