Trial reportJapanese journal of ophthalmology2012
Differential contributions of impaired corneal sensitivity and reduced tear secretion to corneal epithelial disorders.
Trial report in Japanese journal of ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Efficacy and safety of preservative-free versus preserved timolol eye drops in glaucoma: A randomized crossover study.Journal of the Chinese Medical Association : JCMA · 2026Trial
- The Prevalence of Corneal Sensitivity Loss in Patients with and without Dry Eye Disease.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Segmentation and multiparametric evaluation of corneal whorl-like nerves for in vivo confocal microscopy images in dry eye disease.BMJ open ophthalmology · 2024Article
- CGRP Released by Corneal Sensory Nerve Maintains Tear Secretion of the Lacrimal Gland.Investigative ophthalmology & visual science · 2024Article
- Safety and Pitfalls of Blepharoptosis Surgery in Elderly People.Archives of plastic surgery · 2023Article
- The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas.Progress in retinal and eye research · 2022Review
- A Deep Learning Model for Automated Sub-Basal Corneal Nerve Segmentation and Evaluation Using In Vivo Confocal Microscopy.Translational vision science & technology · 2020Article
- Corneal Sensitivity and Tear Function in Recurrent Corneal Erosion Syndrome.Investigative ophthalmology & visual science · 2020Article
- Altered Corneal Nerves in Chinese Thyroid-Associated Ophthalmopathy Patients Observed by In Vivo Confocal Microscopy.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- [Pathogenesis and epidemiology of neurotrophic keratopathy].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019Review
- Corneal nerve healing after in situ laser nerve transection.PloS one · 2019Article
- The Effects of Diabetic Duration on Lacrimal Functional Unit in Patients with Type II Diabetes.Journal of ophthalmology · 2019Article
- An Update on Corneal Biomechanics and Architecture in Diabetes.Journal of ophthalmology · 2019Review
- Corneal Innervation and Sensation: The Eye and Beyond.The Yale journal of biology and medicine · 2018Review
- In vivo confocal microscopy of toxic keratopathy.Eye (London, England) · 2017Article
- Degeneration and Regeneration of Subbasal Corneal Nerves after Infectious Keratitis: A Longitudinal In Vivo Confocal Microscopy Study.Ophthalmology · 2015Article
- Coculture of dorsal root ganglion neurons and differentiated human corneal stromal stem cells on silk-based scaffolds.Journal of biomedical materials research. Part A · 2015Article
- Sensory nerve regeneration after epithelium wounding in normal and diabetic cornea.Expert review of ophthalmology · 2015Article
- Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ.Nature communications · 2013Article
- The role of fibronectin in corneal wound healing explored by a physician-scientist.Japanese journal of ophthalmology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsTo determine the possible roles of impaired corneal sensitivity and reduced tear secretion in various types of corneal epithelial disorders.
methodsA total of 99 patients (179 eyes) with corneal epithelial disorders classified as persistent epithelial defects (PED), corneal erosion, or superficial punctate keratopathy (SPK) and 115 individuals (230 eyes) without apparent ocular surface disorders (controls) were enrolled in a prospective study. Corneal sensitivity was measured with a Cochet-Bonnet esthesiometer, and tear secretion was measured by the Schirmer test in each subject.
resultsCorneal sensitivity of eyes in the PED and corneal erosion groups was significantly lower than that in the control group. Schirmer test values for eyes in the SPK group were significantly reduced compared with those in the control group.
conclusionA loss of corneal sensitivity may contribute to the development of PED and corneal erosion, whereas reduced tear secretion may be a contributing factor for SPK. Both results indicate the importance of corneal sensory innervation to the maintenance of corneal integrity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.