ArticleJournal of mathematical biology2012
A finite-element model for healing of cutaneous wounds combining contraction, angiogenesis and closure.
Article in Journal of mathematical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
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Who cites it
20 citing papers in PubMed.
- A randomized controlled trial of effectiveness of platelet-rich plasma gel and regular dressing on wound healing time in pilonidal sinus surgery: Role of different affecting factors.Biomedical journal · 2019Trial
- A Mathematical Model for Chemo-Mechanically Induced Collective Cell Motility on Planar Elastic Substrates.International journal for numerical methods in biomedical engineering · 2026Article
- Angiogenesis Dynamics: A Computational Model of Intravascular Flow Within a Structural Adaptive Vascular Network.Biomedicines · 2024Article
- Article
- Stability of a two-dimensional biomorphoelastic model for post-burn contraction.Journal of mathematical biology · 2023Article
- On modeling the multiscale mechanobiology of soft tissues: Challenges and progress.Biophysics reviews · 2022Review
- A formalism for modelling traction forces and cell shape evolution during cell migration in various biomedical processes.Biomechanics and modeling in mechanobiology · 2021Article
- Mathematical Modeling Can Advance Wound Healing Research.Advances in wound care · 2021Review
- Article
- Bioinspired mechanically active adhesive dressings to accelerate wound closure.Science advances · 2019Article
- A multiscale hybrid mathematical model of epidermal-dermal interactions during skin wound healing.Experimental dermatology · 2019Article
- Integration ofFrontiers in physiology · 2018Article
- Biomedical implications from a morphoelastic continuum model for the simulation of contracture formation in skin grafts that cover excised burns.Biomechanics and modeling in mechanobiology · 2017Article
- A mathematical model for the simulation of the contraction of burns.Journal of mathematical biology · 2017Article
- A biomechanical mathematical model for the collagen bundle distribution-dependent contraction and subsequent retraction of healing dermal wounds.Biomechanics and modeling in mechanobiology · 2017Article
- A mathematical model for the simulation of the formation and the subsequent regression of hypertrophic scar tissue after dermal wounding.Biomechanics and modeling in mechanobiology · 2017Article
- A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis.Frontiers in physiology · 2017Article
- Review on experiment-based two- and three-dimensional models for wound healing.Interface focus · 2016Review
- On the mathematical modeling of wound healing angiogenesis in skin as a reaction-transport process.Frontiers in physiology · 2015Review
- Nonlinear finite element simulations of injuries with free boundaries: application to surgical wounds.International journal for numerical methods in biomedical engineering · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A simplified finite-element model for wound healing is proposed. The model takes into account the sequential steps of dermal regeneration, wound contraction, angiogenesis and wound closure. An innovation in the present study is the combination of the aforementioned partially overlapping processes, which can be used to deliver novel insights into the process of wound healing, such as geometry related influences, as well as the influence of coupling between the various existing subprocesses on the actual healing behavior. The model confirms the clinical observation that epidermal closure proceeds by a crawling and climbing mechanism at the early stages, and by a stratification process in layers parallel to the skin surface at the later stages. The local epidermal oxygen content may play an important role here. The model can also be used to investigate the influence of local injection of hormones that stimulate partial processes occurring during wound healing. These insights can be used to improve wound healing treatments.
Indexed as
Identifiers
22071653What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.