ArticleMagma (New York, N.Y.)2012
Orientational dependent sensitivities of T2 and T1ρ towards trypsin degradation and Gd-DTPA2- presence in bovine nasal cartilage.
Article in Magma (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
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- High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging.Quantitative imaging in medicine and surgery · 2024Article
- Structural differences between immature and mature articular cartilage of rabbits by microscopic MRI and polarized light microscopy.Journal of anatomy · 2022Article
- Structural Morphology of Rabbit Patella and Suprapatella Cartilage by Microscopic MRI and Polarized Light Microscopy.Cartilage · 2021Article
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- Stabilization of TMagnetic resonance in medicine · 2019Article
- Quantitative measurement of T2, T1ρ and T1 relaxation times in articular cartilage and cartilage-bone interface by SE and UTE imaging at microscopic resolution.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- Multi-parametric MRI characterization of enzymatically degraded articular cartilage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- MRI properties of a unique hypo-intense layer in degraded articular cartilage.Physics in medicine and biology · 2015Article
- Molecular origin of a loading-induced black layer in the deep region of articular cartilage at the magic angle.Journal of magnetic resonance imaging : JMRI · 2015Article
- T1ρ Dispersion in Articular Cartilage: Relationship to Material Properties and Macromolecular Content.Cartilage · 2015Article
- Article
- Experimental issues in the measurement of multi-component relaxation times in articular cartilage by microscopic MRI.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo study the orientational dependencies of T(2) and T(1ρ) in native and trypsin-degraded bovine nasal cartilage, with and without the presence of 1 mM Gd-DTPA(2-). MATERIALS AND
methodsSixteen specimens were prepared in two orthogonal fibril directions (parallel and perpendicular), treated using different protocols (native, Gd treated, trypsin-treated, and combination), and imaged using μMRI at 0° and 55° (the magic angle) fibril orientations with respect to the magnetic field B(0). Two-dimensional (2D) T(2) and T(1ρ) images were then calculated quantitatively.
resultsWithout Gd, native perpendicular tissues demonstrated significant T(1ρ) dispersion (including T(2) at the zero spin-lock field) at 0° and less dispersion at 55°, while native parallel specimens exhibited smaller T(1ρ) dispersion at both 0° and 55°. Trypsin degradation caused a minimum 50% increase in T(1ρ). With Gd, trypsin degradation caused significant reduction in T(1ρ) values up to 60%.
conclusionThe collagen orientation in nasal cartilage can influence T(2) and T(1ρ) MRI of cartilage. Without Gd, T(1ρ) was sensitive to the proteoglycan content and its sensitivity was nearly constant regardless of fibril orientation. In comparison, the T(2) sensitivity to proteoglycan was dependant upon fibril orientation, i.e., more sensitive at 55° than 0°. When Gd ions were present, both T(2) and T(1ρ) became insensitive to the proteoglycan content.
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