ArticleNaunyn-Schmiedeberg's archives of pharmacology2012
Enalapril reduces germ cell toxicity in streptozotocin-induced diabetic rat: investigation on possible mechanisms.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 33 citations in OpenAlex.
- Chronic Stress Destabilizes Ectoplasmic Specialization Dynamics in the Rat Testis via Downregulating the Focal Adhesion Kinase-Associated Protein Complex.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Combination Therapy with Enalapril and Paricalcitol Ameliorates Streptozotocin Diabetes-Induced Testicular Dysfunction in Rats via Mitigation of Inflammation, Apoptosis, and Oxidative Stress.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Article
- Effects of clinical medications on male fertility and prospects for stem cell therapy.Frontiers in cell and developmental biology · 2023Review
- Enalapril stimulates collagen biosynthesis through prolidase-dependent mechanism in cultured fibroblasts.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Diabetes-induced oxidative DNA damage alters p53-p21CIP1/Waf1 signaling in the rat testis.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Dracaena arborea alleviates ultra-structural spermatogenic alterations in streptozotocin-induced diabetic rats.BMC complementary and alternative medicine · 2013Article
- Expression of cyclooxygenase-1 (COX-1) and COX-2 in human male gametes from normal patients, and those with varicocele and diabetes: a potential molecular marker for diagnosing male infertility disorders.Journal of anatomy · 2012Article
- Protective role of Hibiscus sabdariffa calyx extract against streptozotocin induced sperm damage in diabetic rats.EXCLI journal · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus, a state of persistent hyperglycemia, is a major cause of micro- and macrovascular diseases. It affects nearly every system in the body including the reproductive system. Abnormalities in spermatogenesis and sexual function have been documented in animal models for both types of diabetes. The purpose of the present study is to determine the possible protective effects of enalapril against the germ cell toxicity in diabetic rat. Sprague-Dawley rats were divided into four groups: (1) control, (2) control + enalapril, (3) diabetic, and (4) diabetic + enalapril. Enalapril was administered per orally for 4 and 8 weeks continuously. After the treatment, animals were sacrificed and blood glucose level, sperm count, sperm DNA damage, apoptotic cell death, immunohistochemistry of 8-oxo- 7,8-dihydro- 2'-deoxyguanosine, and the cellular toxicity were performed. Furthermore, western blotting was performed to evaluate the expression of NFκB and COX-2 in testes. The results of the present study indicate that intervention of enalapril ameliorates the sperm DNA damage, reduces the oxidative stress, and down-regulates the expression of NFκB and COX-2 expression in streptozotocin-induced diabetic rat.
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