ArticleBioorganic & medicinal chemistry2011
Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation.
Article in Bioorganic & medicinal chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Cross-coupling reactions towards the synthesis of natural products.Molecular diversity · 2022Review
- Synthesis and Evaluation of Paclitaxel-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery.Bioconjugate chemistry · 2016Article
- The quest for a simple bioactive analog of paclitaxel as a potential anticancer agent.Accounts of chemical research · 2014Article
- Conformationally Constrained and Nanoparticle Targeted Paclitaxels.Pure and applied chemistry. Chimie pure et appliquee · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A series of compounds designed to adopt a conformation similar to the tubulin-binding T-Taxol conformation of the anticancer drug paclitaxel has been synthesized. Both the internally bridged analogs 37-39, 41 and the open-chain analogs 27-29 and 43 were prepared. The bridged analogs 37-39 and 41 were synthesized by Grubbs' metatheses of compounds 30-32 and 33, which, in turn, were prepared by coupling β-lactams 24-26 with alcohols 22 and 23. Both the bridged and the open-chain analogs showed moderate to good cytotoxicity.
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