Evidence map›Paper›PMID 22071327›Full record

ReviewAmerican journal of respiratory and critical care medicine2012

Acquisition and processing of endobronchial ultrasound-guided transbronchial needle aspiration specimens in the era of targeted lung cancer chemotherapy.

William Bulman, Anjali Saqi, Charles A Powell

Abstract readReview
In one paragraph

Review in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 74 citations in OpenAlex.

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  18. Update in lung cancer and mesothelioma 2012.American journal of respiratory and critical care medicine · 2013
    Review
  19. Current status and perspective of EBUS-TBNA.General thoracic and cardiovascular surgery · 2013
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

William BulmanDivision of Pulmonary and Critical Care Medicine, Columbia University Medical Center, New York, New York, USA.
Anjali Saqi
Charles A Powell
Pulmonary and Critical Care Associates · USColumbia University Irving Medical Center · US

Funding

Lung Epithelial-Mesenchymal Interactions in Adenocarcinoma InvasionR01CA120174 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI POWELL, CHARLES A. · 2007 to 2011
$1.9M
NCI NIH HHS R01 CA120174NCI NIH HHS R01CA120174
6 · The paper itself

Abstract

Recent advances in therapy for non-small cell lung carcinoma have shown that a personalized approach to treatment has the potential to significantly reduce lung cancer mortality. Concurrently, endoscopic ultrasound transbronchial needle aspiration has emerged as an accurate and sensitive tool for the diagnosis and staging of this disease. As knowledge of the molecular mechanisms that drive lung cancer progression increases, the amount of information that must be derived from a tumor specimen will also increase. Recent clinical studies have demonstrated that small specimens acquired by endoscopic ultrasound transbronchial needle aspiration are sufficient for molecular testing if specimen acquisition and processing are done with these needs in mind. Optimum use of this procedure requires a coordinated effort between the bronchoscopist and the cytopathologist to collect and triage specimens for diagnostic testing. When feasible, rapid onsite evaluation should be performed to assess the specimen for both diagnostic quality and quantity and to allocate the specimen for cell-block and possible immunohistochemistry and molecular studies. It is necessary for pulmonologists and bronchoscopists to understand the rationale for histologic and molecular testing of lung cancer diagnostic specimens and to ensure that specimens are acquired and processed in a fashion that provides information from small cytologic specimens that is sufficient to guide treatment in this era of targeted therapy.

Indexed as

EndosonographyLung NeoplasmsAntineoplastic AgentsBiopsy, NeedleBronchiBronchoscopyHumansReproducibility of ResultsAntineoplastic Agents

Identifiers

PMID22071327
PMCPMC3326290
OpenAlexW2001945129

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.