ArticleThe oncologist2011
Prevalence of Borrelia burgdorferi infection in a series of 98 primary cutaneous lymphomas.
Article in The oncologist, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 66 citations in OpenAlex.
- Unveiling Primary Cutaneous B-Cell Lymphomas: New Insights into Diagnosis and Treatment Strategies.Cancers · 2025Review
- Clinician's perspective on the diagnosis of primary cutaneous B-cell lymphoma.Dermatology reports · 2024Review
- Penicillin in Borrelia burgdorferi-negative Primary Cutaneous Marginal Zone Lymphoma: A Case Series and Literature Review.Acta dermato-venereologica · 2022Review
- Single-Cell Heterogeneity of Cutaneous T-Cell Lymphomas Revealed Using RNA-Seq Technologies.Cancers · 2020Review
- Bidirectional interaction between intestinal microbiome and cancer: opportunities for therapeutic interventions.Biomarker research · 2020Review
- Diagnostic Workup of Primary Cutaneous B Cell Lymphomas: A Clinician's Approach.Frontiers in oncology · 2020Article
- Recent advances in understanding the biology of marginal zone lymphoma.F1000Research · 2018Review
- Novel developments in the pathogenesis and diagnosis of extranodal marginal zone lymphoma.Journal of hematopathology · 2017Review
- [Treatment of indolent cutaneous B‑cell lymphoma].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2017Review
- Managing Patients with Cutaneous B-Cell and T-Cell Lymphomas Other Than Mycosis Fungoides.Current hematologic malignancy reports · 2016Review
- Infectious Aetiology of Marginal Zone Lymphoma and Role of Anti-Infective Therapy.Mediterranean journal of hematology and infectious diseases · 2016Review
- Toll-Like Receptor 1/2 and 5 Ligands Enhance the Expression of Cyclin D1 and D3 and Induce Proliferation in Mantle Cell Lymphoma.PloS one · 2016Article
- The role of infectious agents, antibiotics, and antiviral therapy in the treatment of extranodal marginal zone lymphoma and other low-grade lymphomas.Current treatment options in oncology · 2015Review
- Early lymphoid lesions: conceptual, diagnostic and clinical challenges.Haematologica · 2014Review
- Review
- Cutaneous primary B-cell lymphomas: from diagnosis to treatment.Anais brasileiros de dermatologiaReview
- Marginal Zone Lymphoma: Saudi Lymphoma Group's Clinical Practice Guidelines for Diagnosis, Management and Follow-up.Saudi journal of medicine & medical sciencesArticle
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Borrelia burgdorferi has been variably associated with different forms of primary cutaneous lymphoma. Differences in prevalence rates among reported studies could be a result of geographic variability or heterogeneity in the molecular approaches that have been employed. In the present study, we investigated the prevalence of Borrelia burgdorferi sensu lato DNA in diagnostic tissue samples from fresh cutaneous biopsies of 98 primary cutaneous lymphomas and 19 normal skin controls. Three different polymerase chain reaction (PCR) protocols targeting the hbb, flagellin, and Osp-A genes were used. Direct sequencing of both sense and antisense strands of purified PCR products confirmed the specificity of the amplified fragments. Sequence specificity was assessed using the Basic Local Alignment Search Tool, and MultAlin software was used to investigate the heterogeneity of target gene sequences across the different samples. Borrelia DNA was not detected in 19 controls, 23 cases of follicular lymphoma, 31 cases of extranodal marginal zone lymphoma, or 30 cases of mycosis fungoides. A single case of 14 diffuse large B-cell lymphoma cases was positive for B. burgdorferi. This study does not support a pathogenic role of B. burgdorferi in primary cutaneous B- and T-cell lymphomas from areas nonendemic for this microorganism and the consequent rationale for the adoption of antibiotic therapy in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.