ReviewBMC medicine2011
Closed-loop insulin delivery for treatment of type 1 diabetes.
Review in BMC medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Clinical Effectiveness of Different Technologies for Diabetes in Pregnancy: Systematic Literature Review.Journal of medical Internet research · 2021Pooled it
- Trial
- Hybrid Closed-Loop Insulin Delivery in Type 1 Diabetes During Supervised Outpatient Conditions.Journal of diabetes science and technology · 2016Trial
- Safety, efficacy and glucose turnover of reduced prandial boluses during closed-loop therapy in adolescents with type 1 diabetes: a randomized clinical trial.Diabetes, obesity & metabolism · 2015Trial
- Intradermal insulin infusion achieves faster insulin action than subcutaneous infusion for 3-day wear.Drug delivery and translational research · 2015Trial
- Safety of closed-loop therapy during reduction or omission of meal boluses in adolescents with type 1 diabetes: a randomized clinical trial.Diabetes, obesity & metabolism · 2014Trial
- Enhanced absorption of insulin aspart as the result of a dispersed injection strategy tested in a randomized trial in type 1 diabetic patients.Diabetes care · 2013Trial
- Closed-Loop Bioelectronic Artificial Pancreas Patch for Continuous Monitoring and Regulation of Blood Glucose in Diabetic Rats and Pigs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Event-triggered smart dual hormone artificial pancreas for patient-specific drug delivery.Scientific reports · 2025Article
- Fabrication of 3D Printed Microneedle Patch for the Simultaneous Delivery and Detection of Melatonin from Interstitial Fluid.AAPS PharmSciTech · 2025Article
- Novel Methods to Understand the Temporal Nature and Accuracy of Delivery for Insulin Infusion Pumps.Journal of diabetes science and technology · 2024Article
- Size matters: the biochemical logic of ligand type in endocrine crosstalk.Life metabolism · 2024Article
- User-centered approach in the development of an eHealth tool for self-management skills in functional insulin therapy to prevent complications of diabetes.Preventive medicine reports · 2022Article
- Intelligent automated drug administration and therapy: future of healthcare.Drug delivery and translational research · 2021Review
- A Fully Integrated Closed-Loop System Based on Mesoporous Microneedles-Iontophoresis for Diabetes Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Diabetology 4.0: Scoping Review of Novel Insights and Possibilities Offered by Digitalization.Journal of medical Internet research · 2021Article
- Hydrophobic Tags for Highly Efficient Light-Activated Protein Release.Molecular pharmaceutics · 2019Article
- Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor.eLife · 2019Article
- Polymerizing Insulin with Photocleavable Linkers to Make Light-Sensitive Macropolymer Depot Materials.Macromolecular bioscience · 2016Article
- Continuous subcutaneous insulin infusion therapy for Type 1 diabetes mellitus in children.Irish journal of medical science · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Type 1 diabetes is one of the most common endocrine problems in childhood and adolescence, and remains a serious chronic disorder with increased morbidity and mortality, and reduced quality of life. Technological innovations positively affect the management of type 1 diabetes. Closed-loop insulin delivery (artificial pancreas) is a recent medical innovation, aiming to reduce the risk of hypoglycemia while achieving tight control of glucose. Characterized by real-time glucose-responsive insulin administration, closed-loop systems combine glucose-sensing and insulin-delivery components. In the most viable and researched configuration, a disposable sensor measures interstitial glucose levels, which are fed into a control algorithm controlling delivery of a rapid-acting insulin analog into the subcutaneous tissue by an insulin pump. Research progress builds on an increasing use of insulin pumps and availability of glucose monitors. We review the current status of insulin delivery, focusing on clinical evaluations of closed-loop systems. Future goals are outlined, and benefits and limitations of closed-loop therapy contrasted. The clinical utility of these systems is constrained by inaccuracies in glucose sensing, inter- and intra-patient variability, and delays due to absorption of insulin from the subcutaneous tissue, all of which are being gradually addressed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.