Evidence map›Paper›PMID 22071167›Full record

ArticleJournal of pain and symptom management2012

Development of a prognostic model for six-month mortality in older adults with declining health.

Paul K J Han, Minjung Lee, Bryce B Reeve, Angela B Mariotto, Zhuoqiao Wang, Ron D Hays, K Robin Yabroff, Marie Topor, Eric J Feuer

Abstract read
In one paragraph

Article in Journal of pain and symptom management, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. The impact of knowledge of hospitalization on mortality predictions.Health services & outcomes research methodology · 2025
    Article
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  9. PROMISQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018
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  10. Article
  11. Discussing prognosis and treatment goals with patients with advanced cancer: A qualitative analysis of oncologists' language.Health expectations : an international journal of public participation in health care and health policy · 2017
    Article
  12. Article
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  16. Physicians' perceptions of the value of prognostic models: the benefits and risks of prognostic confidence.Health expectations : an international journal of public participation in health care and health policy · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paul K J HanCenter for Outcomes Research and Evaluation, Maine Medical Center, Portland, ME 04105, USA. hanp@mmc.org
Minjung Lee
Bryce B Reeve
Angela B Mariotto
Zhuoqiao Wang
Ron D Hays
K Robin Yabroff
Marie Topor
Eric J Feuer

Funding

The Center for Health Improvement of Minority ElderlyP30AG021684 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CATHERINE A SARKISIAN · 2002 to 2026
$19.7M
TRAINING COREP20MD000182 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI CUNNINGHAM, WILLIAM EMERY, SHAPIRO, MARTIN F. · 2002 to 2016
$16.5M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
Intramural NIH HHS Z99 CA999999NCI NIH HHS Y99 CA999999NIA NIH HHS P30 AG021684NIA NIH HHS P30AG021684NIA NIH HHS P30 AG028748NIA NIH HHS P30-AG028748NIMHD NIH HHS 2P20MD000182NIMHD NIH HHS P20 MD000182
6 · The paper itself

Abstract

contextEstimation of six-month prognosis is essential in hospice referral decisions, but accurate, evidence-based tools to assist in this task are lacking.

objectivesTo develop a new prognostic model, the Patient-Reported Outcome Mortality Prediction Tool (PROMPT), for six-month mortality in community-dwelling elderly patients.

methodsWe used data from the Medicare Health Outcomes Survey linked to vital status information. Respondents were 65 years old or older, with self-reported declining health over the past year (n=21,870), identified from four Medicare Health Outcomes Survey cohorts (1998-2000, 1999-2001, 2000-2002, and 2001-2003). A logistic regression model was derived to predict six-month mortality, using sociodemographic characteristics, comorbidities, and health-related quality of life (HRQOL), ascertained by measures of activities of daily living and the Medical Outcomes Study Short Form-36 Health Survey; k-fold cross-validation was used to evaluate model performance, which was compared with existing prognostic tools.

resultsThe PROMPT incorporated 11 variables, including four HRQOL domains: general health perceptions, activities of daily living, social functioning, and energy/fatigue. The model demonstrated good discrimination (c-statistic=0.75) and calibration. Overall diagnostic accuracy was superior to existing tools. At cut points of 10%-70%, estimated six-month mortality risk sensitivity and specificity ranged from 0.8% to 83.4% and 51.1% to 99.9%, respectively, and positive likelihood ratios at all mortality risk cut points ≥40% exceeded 5.0. Corresponding positive and negative predictive values were 23.1%-64.1% and 85.3%-94.5%. Over 50% of patients with estimated six-month mortality risk ≥30% died within 12 months.

conclusionThe PROMPT, a new prognostic model incorporating HRQOL, demonstrates promising performance and potential value for hospice referral decisions. More work is needed to evaluate the model.

Indexed as

AlgorithmsHealth StatusMortalityPrognosisActivities of Daily LivingAdultAgedAged, 80 and overAge FactorsComorbidityEthnicityFemaleHumansKaplan-Meier EstimateMaleMiddle Aged

Identifiers

PMID22071167
PMCPMC3289041

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.