ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2012
Glucoprivation in the ventrolateral medulla decreases brown adipose tissue sympathetic nerve activity by decreasing the activity of neurons in raphe pallidus.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Neuropeptide Y suppresses thermogenic and cardiovascular sympathetic nerve activity via Y1 receptors in the paraventricular nucleus and dorsomedial hypothalamus.Journal of neuroendocrinology · 2021Article
- Control of Adipose Cell Browning and Its Therapeutic Potential.Metabolites · 2020Review
- Preoptic area cooling increases the sympathetic outflow to brown adipose tissue and brown adipose tissue thermogenesis.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Activation of TRPV1 in nucleus tractus solitarius reduces brown adipose tissue thermogenesis, arterial pressure, and heart rate.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability.Pflugers Archiv : European journal of physiology · 2018Review
- Hypothalamic or Extrahypothalamic Modulation and Targeted Temperature Management After Brain Injury.Therapeutic hypothermia and temperature management · 2017Review
- Thermoregulatory inversion: a novel thermoregulatory paradigm.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Role played by periaqueductal gray neurons in parasympathetically mediated fear bradycardia in conscious rats.Physiological reports · 2016Article
- Hibernation, Hypothermia and a Possible Therapeutic "Shifted Homeostasis" Induced by Central Activation of A1 Adenosine Receptor (A1AR).Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology · 2016Review
- Neural Control of Energy Expenditure.Handbook of experimental pharmacology · 2016Review
- Central control of body temperature.F1000Research · 2016Review
- Role of VGF-derived carboxy-terminal peptides in energy balance and reproduction: analysis of "humanized" knockin mice expressing full-length or truncated VGF.Endocrinology · 2015Article
- Central nervous system regulation of brown adipose tissue.Comprehensive Physiology · 2014Review
- Central neural regulation of brown adipose tissue thermogenesis and energy expenditure.Cell metabolism · 2014Review
- Autonomic regulation of brown adipose tissue thermogenesis in health and disease: potential clinical applications for altering BAT thermogenesis.Frontiers in neuroscience · 2014Review
- Hindbrain catecholamine neurons control rapid switching of metabolic substrate use during glucoprivation in male rats.Endocrinology · 2013Article
- Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- K(ATP)-channel-dependent regulation of catecholaminergic neurons controls BAT sympathetic nerve activity and energy homeostasis.Cell metabolism · 2013Article
- C1 neurons: the body's EMTs.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Review
- α2 Adrenergic receptor-mediated inhibition of thermogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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Abstract
In urethane/α-chloralose anesthetized rats, cold exposure increased brown adipose tissue sympathetic nerve activity (BAT SNA: +699 ± 104% control). Intravenous administration of 2-deoxy-D-glucose (2-DG; 200 mg·ml(-1)·kg(-1)) reversed the cold-evoked activation of BAT SNA (nadir: 139 ± 36% of control) and decreased BAT temperature (-1.1 ± 0.2°C), expired CO(2) (-0.4 ± 0.1%), and core temperature (-0.5 ± 0.0). Similarly, unilateral nanoinjection of the glucoprivic agent 5-thioglucose (5-TG; 12 μg/100 nl) in the ventrolateral medulla (VLM) completely reversed the cold-evoked increase in BAT SNA (nadir: 104 ± 7% of control), and decreased T(BAT) (-1.4 ± 0.3°C), expired CO(2) (-0.2 ± 0.0%), and heart rate (-35 ± 10 beats/min). The percentage of rostral raphé pallidus (RPa)-projecting neurons in the dorsal hypothalamic area/dorsomedial hypothalamus that expressed Fos in response to cold exposure (ambient temperature: 4-10°C) did not differ between saline (28 ± 6%) and 2-DG (30 ± 5%) pretreated rats, whereas the percentage of spinally projecting neurons in the RPa/raphé magnus that expressed Fos in response to cold exposure was lower in 2-DG- compared with saline-pretreated rats (22 ± 6% vs. 42 ± 5%, respectively). The increases in BAT SNA evoked by nanoinjection of bicuculline in the RPa or by transection of the neuraxis at the pontomedullary border were resistant to inhibition by glucoprivation. These results suggest that neurons within the VLM play a role in the glucoprivic inhibition of BAT SNA and metabolism, that this inhibition requires neural structures rostral to the pontomedullary border, and that this inhibition is mediated by a GABAergic input to the RPa.
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