ArticleBMC neurology2011
Clinical characteristics and favorable long-term outcomes for patients with idiopathic inflammatory myopathies: a retrospective single center study in China.
Article in BMC neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Plasma exchange in adult idiopathic inflammatory myositis: a systematic review and meta-analysis.Clinical rheumatology · 2026Pooled it
- Health-Related Quality of Life (HRQoL) in Idiopathic Inflammatory Myopathy: A Systematic Review.PloS one · 2016Pooled it
- Clinical characteristics and risk factors associated with objective flares in patients with dermatomyositis.Seminars in arthritis and rheumatism · 2026Article
- Long-term oral glucocorticoid use is associated with complications, healthcare resource utilization, and costs among patients with dermatomyositis or polymyositis.Clinical rheumatology · 2025Article
- Neutrophil extracellular traps are involved in the occurrence of interstitial lung disease in a murine experimental autoimmune myositis model.Clinical and experimental immunology · 2024Article
- Long Term Outcomes in Idiopathic Inflammatory Myositis: An Observational Epidemiologic Study over 15 Years.Mediterranean journal of rheumatology · 2023Article
- Low serum level of citrullinated histone H3 in patients with dermatomyositis.Journal of clinical laboratory analysis · 2023Article
- Autoimmune Idiopathic Inflammatory Myopathies: Pharmacological Differences and Similarities by Type of Myositis and by Sociodemographic Variables.International journal of rheumatology · 2022Article
- Mycophenolate in idiopathic inflammatory myositis: outcome data of a large South Asian cohort.Clinical rheumatology · 2021Article
- Neutrophil extracellular traps activate lung fibroblast to induce polymyositis-related interstitial lung diseases via TLR9-miR-7-Smad2 pathway.Journal of cellular and molecular medicine · 2020Article
- Acute Exacerbation of Interstitial Lung Disease in Adult Patients With Idiopathic Inflammatory Myopathies: A Retrospective Case-Control Study.Frontiers in medicine · 2020Article
- Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis.Journal of translational medicine · 2019Article
- Disability in idiopathic inflammatory myopathies: questionnaire-based study.Rheumatology international · 2019Article
- Serum-soluble TRAIL: a potential biomarker for disease activity in myositis patients.Clinical rheumatology · 2019Article
- Idiopathic Inflammatory Myopathies and Malignancy: a Comprehensive Review.Clinical reviews in allergy & immunology · 2017Review
- The Correlation of Muscle Biopsy Scores with the Clinical Variables in Idiopathic Inflammatory Myopathies.The open rheumatology journal · 2016Article
- Early illness features associated with mortality in the juvenile idiopathic inflammatory myopathies.Arthritis care & research · 2014Article
- Long-term follow-up of 62 patients with myositis.Journal of neurology · 2014Article
- Expression of tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 in patients with polymyositis and dermatomyositis.Arthritis research & therapy · 2014Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the clinical features and true survival risk factors in Chinese Han population. We conducted the current study to investigate the clinical features, long-term outcome and true potential indicators associated with mortality of idiopathic inflammatory myopathies (IIM) in China.
methodsWe restrospectvely investigated 188 patients diagnosed with IIM at our hospital from January 1986 to April 2009. The primary outcome was determined with mortality. The secondary outcomes for survival patients were organ damage and disease activity, health status, and disability, which were assessed with Myositis Damage Index, Myositis Disease Activity Assessment Visual Analogue Scales, Health Assessment Questionnaire Disability Index, and the Modified Rankin Scale, respectively. Potential prognostic factors for mortality were analyzed with the multivariate Cox regression model.
resultsMean age at disease onset was 43.8 ± 15.8 years and male to female ratio was 1:2.1 in this cohort. The 1-, 5-, 10-, 15- and 20-year survival rates were 93.6%, 88.7%, 81%, 73.6% and 65.6%. The independent predicators for mortality were age at disease onset [hazard ratio (HR):1.05, 95% CI 1.02 - 1.08], presence of cancer (HR:3.68, 95%CI 1.39 - 9.74), and elevated IgA level at diagnosis (HR:2.80, 95% CI 1.16-6.74). At the end of the follow-up, 29 patients manifested drug withdrawal within an average 4.1 years (range 0.5-15.2 year), most patients (85.9%) had no disease activity and 130 patients (83.4%) had no disability.
conclusionsThe long-term outcomes of IIM patients in our cohort have improved dramatically. Those patients most likely to survive had a high chance of reaching stable disease status, and obtained long-term or possibly permanent remission to a large extent.
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