ArticleThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry2014
Olfactory processing in schizophrenia, non-ill first-degree family members, and young people at-risk for psychosis.
Article in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Olfactory Dysfunction in Neurodevelopmental Disorders: A Meta-analytic Review of Autism Spectrum Disorders, Attention Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder.Journal of autism and developmental disorders · 2020Pooled it
- Meta-analysis of olfactory function in schizophrenia, first-degree family members, and youths at-risk for psychosis.Schizophrenia bulletin · 2014Pooled it
- A systematic review on olfaction in child and adolescent psychiatric disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2013Pooled it
- Effects of adjunctive intranasal oxytocin on olfactory identification and clinical symptoms in schizophrenia: results from a randomized double blind placebo controlled pilot study.Schizophrenia research · 2013Trial
- Correlation Between Cortical Thickness Abnormalities of the Olfactory Sulcus and Olfactory Identification Disorder and Persistent Auditory Verbal Hallucinations in Chinese Patients With Chronic Schizophrenia.Schizophrenia bulletin · 2024Article
- Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders.Molecular psychiatry · 2024Article
- Unraveling the Link between Olfactory Deficits and Neuropsychiatric Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Brain regions associated with olfactory dysfunction in first episode psychosis patients.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2023Article
- Deficits in odor discrimination versus odor identification in patients with schizophrenia and negative correlations with GABAergic and DNA methyltransferase mRNAs in lymphocytes.Frontiers in psychiatry · 2023Article
- Olfactory impairment in psychiatric disorders: Does nasal inflammation impact disease psychophysiology?Translational psychiatry · 2022Review
- Odor Identification Ability as a Mediator of Schizotypal Traits and Odor Hedonic Capacity in Non-Clinical Children and Adolescents.Brain sciences · 2022Article
- International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022Review
- Association between olfactory sulcus morphology and olfactory functioning in schizophrenia and psychosis high-risk status.Heliyon · 2019Article
- Contributions of olfactory and neuropsychological assessment to the diagnosis of first-episode schizophrenia.Neuropsychology · 2019Article
- Olfactory deficits and psychosis-spectrum symptoms in 22q11.2 deletion syndrome.Schizophrenia research · 2018Article
- Olfactory deficits in individuals at risk for psychosis and patients with schizophrenia: relationship with socio-cognitive functions and symptom severity.European archives of psychiatry and clinical neuroscience · 2018Article
- Structural anomalies of the peripheral olfactory system in psychosis high-risk subjects.Schizophrenia research · 2018Article
- Olfactory Functioning in First-Episode Psychosis.Schizophrenia bulletin · 2018Article
- Temporal Lobe Volume Decrements in Psychosis Spectrum Youths.Schizophrenia bulletin · 2017Article
- Altered G Protein Coupling in Olfactory Neuroepithelial Cells From Patients With Schizophrenia.Schizophrenia bulletin · 2016Article
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Abstract
objectivesWhile deficits in odor identification and discrimination have been reported in schizophrenia, few studies have examined the relative specificity of these deficits in patients and at-risk youth.
methodSniffin' Sticks odor identification and discrimination were assessed in schizophrenia outpatients and non-ill first-degree relatives (Study One), as well as youth at clinical (CR) or genetic (GR) risk for schizophrenia (Study Two). Scores were z-transformed, using the performance of a demographically-matched adult or adolescent comparison group.
resultsPatients and relatives were impaired on odor identification, but odor discrimination impairment was limited to the patient group. A similar pattern of impairment emerged in at-risk youth. GR youth were impaired on odor identification but not discrimination, while CR youth were impaired on both tasks. In patients, olfactory impairment was correlated with negative symptomatology.
conclusionsTo our knowledge, this is the first study to show that CR youth are impaired on both olfactory tasks, as observed in adult schizophrenia patients. GR youth were impaired only on odor identification like their adult counterparts. These data suggest that odor identification impairment, in isolation, may represent a genetic marker of vulnerability for schizophrenia, while odor discrimination deficits may be a biomarker associated with the development of psychosis.
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