Evidence map›Paper›PMID 22069601›Full record

ReviewToxins2010

Biological profile of erucin: a new promising anticancer agent from cruciferous vegetables.

Antonietta Melchini, Maria H Traka

Open access · goldAbstract readReview
In one paragraph

Review in Toxins, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
  2. Article
  3. Erucin, a Natural Isothiocyanate, Prevents Polyglutamine-Induced Toxicity inInternational journal of molecular sciences · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Hydrogen Sulfide (HInternational journal of molecular sciences · 2024
    Article
  8. Article
  9. Article
  10. Erucin, an HInternational journal of molecular sciences · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Phytochemical and In Silico ADME/Tox Analysis ofMolecules (Basel, Switzerland) · 2022
    Article
  18. Article
  19. Glucosinolate Bioactivation byBiomolecules · 2021
    Article
  20. The HAntioxidants (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Antonietta MelchiniFoundation "Prof. Antonio Imbesi", Pharmaco-Biological Department, School of Pharmacy, University of Messina/Villaggio Annunziata, 98168 Messina, Italy. amelchini@pharma.unime.it
Maria H Traka
Norwich Research Park · GBUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Consumption of cruciferous vegetables has been associated with a reduced risk in the development of various types of cancer. This has been attributed to the bioactive hydrolysis products that are derived from these vegetables, namely isothiocyanates. Erucin is one such product derived from rocket salads, which is structurally related to sulforaphane, a well-studied broccoli-derived isothiocyanate. In this review, we present current knowledge on mechanisms of action of erucin in chemoprevention obtained from cell and animal models and relate it to other isothiocyanates. These mechanisms include modulation of phase I, II and III detoxification, regulation of cell growth by induction of apoptosis and cell cycle arrest, induction of ROS-mechanisms and regulation androgen receptor pathways.

Indexed as

AnimalsAnticarcinogenic AgentsAntineoplastic Agents, PhytogenicBrassicaceaeCell ProliferationDown-RegulationHumansReactive Oxygen SpeciesReceptors, AndrogenSignal TransductionSulfidesThiocyanatesXenobioticsAnticarcinogenic AgentsAntineoplastic Agents, PhytogenicerucinReactive Oxygen SpeciesReceptors, AndrogenSulfidesThiocyanatesXenobioticsanticancer agentserucinisothiocyanatesrocket salads

Identifiers

PMID22069601
PMCPMC3153205
OpenAlexW1969675634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.