ArticlePloS one2011
Lack of adherence to isoniazid chemoprophylaxis in children in contact with adults with tuberculosis in Southern Ethiopia.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00456469 (Diagnosis of Active and Latent TB Infection With IFN-y Assays in African Children), which is not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diagnosis of Active and Latent TB Infection With IFN-y Assays in African Children
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Strategies to detect and manage latent tuberculosis infection among household contacts of pulmonary TB patients in high TB burden countries - a systematic review and meta-analysis.Tropical medicine & international health : TM & IH · 2022Pooled it
- Child contact management in high tuberculosis burden countries: A mixed-methods systematic review.PloS one · 2017Pooled it
- Clinical practice guideline for the evaluation, treatment, and follow-up of children in contact with patients with pulmonary tuberculosis in Colombia.Colombia medica (Cali, Colombia)Guideline
- Adherence to isoniazid preventive therapy among child contacts in Rwanda: A mixed-methods study.PloS one · 2019Trial
- Impact of isoniazid preventive therapy on the evaluation of long-term effectiveness of infant MVA85A vaccination.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017Trial
- A randomized controlled study of socioeconomic support to enhance tuberculosis prevention and treatment, Peru.Bulletin of the World Health Organization · 2017Trial
- Mapping facility-based tuberculosis preventive treatment provision in Ethiopia: a geospatial analysis.BMC health services research · 2026Article
- The effectiveness of preventive tuberculosis treatment in children.BMC infectious diseases · 2026Article
- Article
- Relationship of family caregivers' associated factors with medication adherence among elderly with tuberculosis in Iran.Journal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- They do not have symptoms - why do they need to take medicines? Challenges in tuberculosis preventive treatment among children in Cambodia: a qualitative study.BMC pulmonary medicine · 2023Article
- Implementation of an integrated care strategy for child contacts of tuberculosis patients: a quasi-experimental study protocol.BMC pediatrics · 2023Article
- Completion of 6-mo isoniazid preventive treatment among eligible under six children: A cross-sectional study, Lagos, Nigeria.World journal of clinical cases · 2023Article
- Social Determinants of Adherence to Treatment for Tuberculosis Infection and Disease Among Children, Adolescents, and Young Adults: A Narrative Review.Journal of the Pediatric Infectious Diseases Society · 2022Review
- Article
- Telehealth Reduces Missed Appointments in Pediatric Patients with Tuberculosis Infection.Tropical medicine and infectious disease · 2022Article
- Caregivers' knowledge and perceptions are associated with children's TB preventive treatment completion.Public health action · 2021Article
- Implementation of isoniazid preventive therapy in southern Lima, Peru: an analysis of health center characteristics.Infectious diseases of poverty · 2021Article
- Closing the loop in child TB contact management: completion of TB preventive therapy outcomes in western Kenya.BMJ open · 2021Article
- Adherence to Isoniazid Preventive Therapy among Under-Five Children in Contact with Adult Bacteriologically Confirmed Pulmonary Tuberculosis Patients: A Mixed-Method Study.International journal of microbiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
settingHawassa, Southern Region of Ethiopia.
objectivesTo determine compliance to isoniazid (INH) preventive therapy (IPT) and its effectiveness in preventing (TB) disease in children in contact with adults with pulmonary TB (PTB).
designThis was a prospective cohort study of children <15 years old in contact with adults with smear-positive PTB. Asymptomatic children ≤5 years were provided IPT independently of their Tuberculin Skin Test (TST) status and children >5 years old were given advice but did not receive IPT, as recommended by the National TB control programme. Compliance to IPT and incidence of clinical TB were determined monthly for six months and then quarterly for up to 30 months.
resultsOne hundred and eighty four children in contact with 83 smear-positive PTB cases were identified. Eighty two were ≤5 and 102>5 years old. Only 27 (33%) of 82 children given IPT took it for >4 months and 10 (12%) completed the 6-month course. The main reason for non-compliance was the perception that drugs were not necessary when the child was healthy. Eleven children (all except one >5 years old) developed symptoms of TB disease and initiated treatment, resulting in an incidence of 28.6 cases for all and 53.5 for children >5 years old per 1000 children-year.
conclusionCompliance to IPT in children is poor in Southern Region of Ethiopia and this was associated with the parents' perception of the low importance of chemoprophylaxis in asymptomatic children. Poor compliance might be an important barrier for the wider implementation of IPT.
trial registrationClinicaltrials.gov NCT00456469.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.