ArticleFrontiers in human neuroscience2011
Broader visual orientation tuning in patients with schizophrenia.
Article in Frontiers in human neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 50 citations in OpenAlex.
- Anodal transcranial direct current stimulation reduces psychophysically measured surround suppression in the human visual cortex.PloS one · 2012Trial
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- Assessing Trial-by-Trial Electrophysiological and Behavioral Markers of Attentional Control and Sensory Precision in Psychotic and Mood Disorders.Schizophrenia bulletin · 2025Article
- Altered Use of Context During Visual Perception in Psychotic Psychopathology: A Neurophysiological Investigation of Tuned and Untuned Suppression During Contrast Perception.Schizophrenia bulletin · 2024Article
- Visual salience is affected in participants with schizophrenia during free-viewing.Scientific reports · 2024Article
- Stronger tilt aftereffects in individuals diagnosed with schizophrenia spectrum disorders but not bipolar disorder.Schizophrenia research · 2024Article
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- Weakened untuned gain control is associated with schizophrenia while atypical orientation-tuned suppression depends on visual acuity.Journal of vision · 2023Article
- Cognitive [Computational] Neuroscience Test Reliability and Clinical Applications for Serious Mental Illness (CNTRaCS) Consortium: Progress and Future Directions.Current topics in behavioral neurosciences · 2023Article
- Computational modeling of excitatory/inhibitory balance impairments in schizophrenia.Schizophrenia research · 2022Article
- Neurochemical and functional interactions for improved perceptual decisions through training.Journal of neurophysiology · 2022Article
- Functional Interactions between Sensory and Memory Networks for Adaptive Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Stronger tilt aftereffects in persons with schizophrenia.Journal of abnormal psychology · 2021Article
- The Phenomenology and Neurobiology of Visual Distortions and Hallucinations in Schizophrenia: An Update.Frontiers in psychiatry · 2021Review
- Spatiotemporal regulation of GABA concentration in extracellular space by gliotransmission crucial for extrasynaptic receptor-mediated improvement of sensory tuning performance in schizophrenia.Journal of computational neuroscience · 2020Article
- Improvement on visual cognitive training exercises in schizophrenia is present but less robust than in healthy individuals.Schizophrenia research · 2020Article
- A review of visual aftereffects in schizophrenia.Neuroscience and biobehavioral reviews · 2019Review
- Altered short-term neural plasticity related to schizotypal traits: Evidence from visual adaptation.Schizophrenia research · 2019Article
- fMRI evidence of aberrant neural adaptation for objects in schizophrenia and bipolar disorder.Human brain mapping · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduced gamma-aminobutyric acid (GABA) levels in cerebral cortex are thought to contribute to information processing deficits in patients with schizophrenia (SZ), and we have previously reported lower in vivo GABA levels in the visual cortex of patients with SZ. GABA-mediated inhibition plays a role in sharpening orientation tuning of visual cortical neurons. Therefore, we predicted that tuning for visual stimulus orientation would be wider in SZ. We measured orientation tuning with a psychophysical procedure in which subjects performed a target detection task of a low-contrast oriented grating, following adaptation to a high-contrast grating. Contrast detection thresholds were determined for a range of adapter-target orientation offsets. For both SZ and healthy controls, contrast thresholds decreased as orientation offset increased, suggesting that this tuning curve reflects the selectivity of visual cortical neurons for stimulus orientation. After accounting for generalized deficits in task performance in SZ, there was no difference between patients and controls for detection of target stimuli having either the same orientation as the adapter or orientations far from the adapter. However, patients' thresholds were significantly higher for intermediate adapter-target offsets. In addition, the mean width parameter of a Gaussian fit to the psychophysical orientation tuning curves was significantly larger for the patient group. We also present preliminary data relating visual cortical GABA levels, as measured with magnetic resonance spectroscopy, and orientation tuning width. These results suggest that our finding of broader orientation tuning in SZ may be due to diminished visual cortical GABA levels.
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