ArticleFrontiers in neural circuits2011
Cholinergic partition cells and lamina x neurons induce a muscarinic-dependent short-term potentiation of commissural glutamatergic inputs in lumbar motoneurons.
Article in Frontiers in neural circuits, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Changes in Spinal Neural Circuit Plasticity in a Rat Sciatic Nerve Transection Model.Brain and behavior · 2026Article
- Synergistic mechanisms of medullary cholinergic-serotonergic pathway interactions in regulating neuronal excitability and locomotor activities.Communications biology · 2025Article
- Approach for Electrophysiological Studies of Spinal Lamina X Neurons.Bio-protocol · 2024Article
- Cholinergic Modulation of Locomotor Circuits in Vertebrates.International journal of molecular sciences · 2022Review
- Acetylcholine and spinal locomotor networks: The insider.Physiological reports · 2021Review
- Resting-state brain and spinal cord networks in humans are functionally integrated.PLoS biology · 2020Article
- Article
- Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors.Scientific reports · 2019Article
- Cholinergic-mediated coordination of rhythmic sympathetic and motor activities in the newborn rat spinal cord.PLoS biology · 2018Article
- Spinal cholinergic interneurons differentially control motoneuron excitability and alter the locomotor network operational range.Scientific reports · 2018Article
- Functional Characterization of Lamina X Neurons inFrontiers in cellular neuroscience · 2017Article
- Co-expression of GAD67 and choline acetyltransferase in neurons in the mouse spinal cord: A focus on lamina X.Brain research · 2016Article
- Distinct and developmentally regulated activity-dependent plasticity at descending glutamatergic synapses on flexor and extensor motoneurons.Scientific reports · 2016Article
- Selective loss of alpha motor neurons with sparing of gamma motor neurons and spinal cord cholinergic neurons in a mouse model of spinal muscular atrophy.Journal of anatomy · 2016Article
- Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.Acta neuropathologica communications · 2016Article
- Age-Related Changes in Pre- and Postsynaptic Partners of the Cholinergic C-Boutons in Wild-Type and SOD1G93A Lumbar Motoneurons.PloS one · 2015Article
- Cholinergic mechanisms in spinal locomotion-potential target for rehabilitation approaches.Frontiers in neural circuits · 2014Article
- Anatomy and function of cholinergic C bouton inputs to motor neurons.Journal of anatomy · 2014Review
- Nanomolar oxytocin synergizes with weak electrical afferent stimulation to activate the locomotor CpG of the rat spinal cord in vitro.PloS one · 2014Article
- A novel population of cholinergic neurons in the macaque spinal dorsal horn of potential clinical relevance for pain therapy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Acetylcholine and the activation of muscarinic receptors influence the activity of neural networks generating locomotor behavior in the mammalian spinal cord. Using electrical stimulations of the ventral commissure, we show that commissural muscarinic (CM) depolarizations could be induced in lumbar motoneurons. We provide a detailed electrophysiological characterization of the muscarinic receptors and the membrane conductance involved in these responses. Activation of the CM terminals, originating from lamina X neurons and partition cells, induced a pathway-specific short-term potentiation (STP) of commissural glutamatergic inputs in motoneurons. This STP is occluded in the presence of the muscarinic antagonist atropine. During fictive locomotion, the activation of the commissural pathways transiently enhanced the motor output in a muscarinic-dependent manner. This study describes for the first time a novel regulatory mechanism of synaptic strength in spinal locomotor networks. Such cellular mechanisms would endow the locomotor central pattern generators with adaptive processes needed to generate appropriate synaptic inputs to motoneurons during different motor tasks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.