ArticlePLoS biology2011
De novo genesis of enhancers in vertebrates.
Article in PLoS biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Emergence Biases in Molecular Evolution.Genome biology and evolution · 2026Review
- De Novo Genes.Annual review of genetics · 2024Review
- Review
- Shifting landscapes: the role of 3D genomic organizations in gene regulatory strategies.Current opinion in genetics & development · 2023Review
- Review
- Enhancer architecture and chromatin accessibility constrain phenotypic space during Drosophila development.Developmental cell · 2023Article
- Developmental and evolutionary comparative analysis of a regulatory landscape in mouse and chicken.Development (Cambridge, England) · 2022Article
- Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers.Nature communications · 2022Article
- Evolution of mouse circadian enhancers from transposable elements.Genome biology · 2021Article
- Mechanisms of enhancer action: the known and the unknown.Genome biology · 2021Review
- Deep Convergence, Shared Ancestry, and Evolutionary Novelty in the Genetic Architecture ofGenetics · 2020Article
- Comprehensive analysis ofCancer cell international · 2020Article
- Redundant and Cryptic Enhancer Activities of theGenetics · 2019Article
- A Collection of Transgenic Medaka Strains for Efficient Site-Directed Transgenesis Mediated by phiC31 Integrase.G3 (Bethesda, Md.) · 2018Article
- Evolutionary emergence of theProceedings of the National Academy of Sciences of the United States of America · 2018Article
- A de novo silencer causes elimination of MITF-M expression and profound hearing loss in pigs.BMC biology · 2016Article
- MEPD: medaka expression pattern database, genes and more.Nucleic acids research · 2016Article
- Evolution of lineage-specific functions in ancient cis-regulatory modules.Open biology · 2015Article
- Article
- Unraveling the Tangled Skein: The Evolution of Transcriptional Regulatory Networks in Development.Annual review of genomics and human genetics · 2015Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evolutionary innovation relies partially on changes in gene regulation. While a growing body of evidence demonstrates that such innovation is generated by functional changes or translocation of regulatory elements via mobile genetic elements, the de novo generation of enhancers from non-regulatory/non-mobile sequences has, to our knowledge, not previously been demonstrated. Here we show evidence for the de novo genesis of enhancers in vertebrates. For this, we took advantage of the massive gene loss following the last whole genome duplication in teleosts to systematically identify regions that have lost their coding capacity but retain sequence conservation with mammals. We found that these regions show enhancer activity while the orthologous coding regions have no regulatory activity. These results demonstrate that these enhancers have been de novo generated in fish. By revealing that minor changes in non-regulatory sequences are sufficient to generate new enhancers, our study highlights an important playground for creating new regulatory variability and evolutionary innovation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.