ArticleInternational journal of chronic obstructive pulmonary disease2011
Determinants of polypharmacy and compliance with GOLD guidelines in patients with chronic obstructive pulmonary disease.
Article in International journal of chronic obstructive pulmonary disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Improving medication adherence in chronic obstructive pulmonary disease: a systematic review.Respiratory research · 2013Pooled it
- Lay Health Coaching to Increase Appropriate Inhaler Use in COPD: A Randomized Controlled Trial.Annals of family medicine · 2020Trial
- An encapsulated juice powder concentrate improves markers of pulmonary function and cardiovascular risk factors in heavy smokers.Journal of the American College of Nutrition · 2013Trial
- Polypharmacy in Patients With COPD: A Scoping Review.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Analysis of longitudinal patterns and predictors of medicine use in residential aged care using group-based trajectory modelling: The MEDTRAC-Polypharmacy longitudinal cohort study.British journal of clinical pharmacology · 2024Article
- Assessment of Medication Adherence Using Mobile Applications in Chronic Obstructive Pulmonary Disease: A Scoping Review.International journal of environmental research and public health · 2024Article
- Association between medication complexity and follow-up care attendance: insights from a retrospective multicenter cohort study across 1,223 Chinese hospitals.Frontiers in pharmacology · 2024Article
- The efficacy of three-ball breathing apparatus exercise based on the concept of pulmonary rehabilitation in patients after lung cancer surgery.Journal of cardiothoracic surgery · 2023Article
- Association between medication adherence and health-related quality of life in patients with chronic obstructive pulmonary disease.Journal of pharmaceutical health care and sciences · 2021Article
- Article
- Frailty and chronic respiratory disease: the need for a multidisciplinary care model.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2021Article
- Aspiration and severe exacerbations in COPD: a prospective study.ERJ open research · 2021Article
- Overuse and Misuse of Inhaled Corticosteroids Among Veterans with COPD: a Cross-sectional Study Evaluating Targets for De-implementation.Journal of general internal medicine · 2020Article
- A multicentric cross-sectional study to characterize the scale and impact of polypharmacy in rural Indian communities, conducted as part of health workers training.Journal of family medicine and primary care · 2019Article
- Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies.Pharmacology & therapeutics · 2019Review
- Inhaled corticosteroid use by exacerbations and eosinophils: a real-world COPD population.International journal of chronic obstructive pulmonary disease · 2019Observational
- Working smarter not harder: Coupling implementation to de-implementation.Healthcare (Amsterdam, Netherlands) · 2018Article
- Polypharmacy among patients with diabetes: a cross-sectional retrospective study in a tertiary hospital in Saudi Arabia.BMJ open · 2018Article
- Burden of asthma and COPD overlap (ACO) in Taiwan: a nationwide population-based study.BMC pulmonary medicine · 2018Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolypharmacy of respiratory medications is commonly observed in patients with chronic obstructive pulmonary disease (COPD). The aims of this study were to investigate determinants of polypharmacy and to study the consistency of actual respiratory drug use with current Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines in pulmonary rehabilitation candidates with COPD.
methodsData were extracted from the records of all patients with a diagnosis of COPD referred for pulmonary rehabilitation to CIRO+ between 2005 and 2009. Use of respiratory medications, self-reported COPD exacerbations, lung function, blood gases, exercise capacity, Medical Research Council (MRC) dyspnea grade, and St George's Respiratory Questionnaire (SGRQ) were recorded as part of assessment of health status.
resultsIn total, 1859 COPD patients of mean age (± standard deviation) 64.3 ± 9.7 years and with a forced expiratory volume in one second (FEV(1)) of 44.7% ± 18.2% were included. On average, patients used 3.5 ± 1.5 respiratory medications; this number increased with increasing GOLD stage, MRC score, and SGRQ scores. FEV(1) (% predicted), SGRQ, and number of recent exacerbations were independent determinants of polypharmacy. Use of long-acting bronchodilators and inhaled corticosteroids was substantial and comparable in all GOLD stages. Use of corticosteroids was not restricted to patients with frequent exacerbations.
conclusionPolypharmacy of respiratory medications is common in COPD patients with persistent symptoms. In addition to severity of disease, health status is an independent predictor of polypharmacy. Actual drug use in COPD patients referred for pulmonary rehabilitation is partially inconsistent with current GOLD guidelines.
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