ArticleDiabetes/metabolism research and reviews2011
Imaging the pancreatic vasculature in diabetes models.
Article in Diabetes/metabolism research and reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Application of Nanoparticles: Diagnosis, Therapeutics, and Delivery of Insulin/Anti-Diabetic Drugs to Enhance the Therapeutic Efficacy of Diabetes Mellitus.Life (Basel, Switzerland) · 2022Review
- Imaging NF-κB activity in a murine model of early stage diabetes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Pancreatic imaging: Current status of clinical practices and small animal studies.World journal of methodology · 2017Review
- Label-free fast 3D coherent imaging reveals pancreatic islet micro-vascularization and dynamic blood flow.Biomedical optics express · 2016Article
- Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging.Diabetologia · 2016Article
- Diagnostic and prognostic utility of non-invasive imaging in diabetes management.World journal of diabetes · 2015Review
- Immune rejection after pancreatic islet cell transplantation: in vivo dual contrast-enhanced MR imaging in a mouse model.Radiology · 2013Article
- Theranostic magnetic resonance imaging of type 1 diabetes and pancreatic islet transplantation.Quantitative imaging in medicine and surgery · 2012Article
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Authors and funding
9 authors at 4 institutions in 1 country.
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Abstract
backgroundVascular parameters, such as vascular volume, flow, and permeability, are important disease biomarkers for both type 1 and type 2 diabetes. Therefore, it is essential to develop approaches to monitor the changes in pancreatic microvasculature non-invasively.
methodsHere, we describe the application of the long-circulating, paramagnetic T1 contrast agent, protected Graft Copolymer bearing covalently linked gadolinium diethylenetriaminepentaacetic acid residues and labelled with fluorescein (PGC-GdDTPA-F) for the non-invasive semi-quantitative evaluation of vascular changes in diabetic models using magnetic resonance imaging.
resultsWe observed a significantly higher accumulation of protected graft copolymer bearing covalently linked gadolinium diethylenetriaminepentaacetic acid residues and labelled with fluorescein in the pancreata of BBDR rats induced to develop diabetes, as compared to non-diabetic controls at 1 h post-injection. No differences were seen in the blood pool, kidney, or muscle, indicating that the effect is specific to the diabetic pancreas. Fluorescence microscopy revealed a marked increase in contrast agent availability in the pancreas with the development of the pathology. Similar changes were noted in the homozygous Leprdb mouse model of type 2 diabetes. This effect appeared to result both from the increase of vascular volume and permeability.
conclusionsHigh-molecular weight paramagnetic blood volume contrast agents are valuable for the in vivo definition of pancreatic microvasculature dynamics by magnetic resonance imaging. The increase in vascular volume and permeability, associated with diabetic inflammation, can be monitored non-invasively and semi-quantitatively by magnetic resonance imaging in diabetic BBDR rats. This imaging strategy represents a valuable research tool for better understanding of the pathologic process.
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