ArticleSao Paulo medical journal = Revista paulista de medicina2011
Canonical and noncanonical Wnt pathways: a comparison between endometrial cancer type I and atrophic endometrium in Brazil.
Article in Sao Paulo medical journal = Revista paulista de medicina, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Association of Membranous WNT-1 and Nuclear mTOR with Endometrial Cancer Grade.International journal of molecular sciences · 2023Article
- Addressing activation of WNT beta-catenin pathway in diverse landscape of endometrial carcinogenesis.American journal of translational research · 2021Review
- Cancer chemoprevention through Frizzled receptors and EMT.Discover oncology · 2021Review
- Changes in the expression of Notch and Wnt signalling molecules in human endometrial cancer.Acta medica Lituanic · 2019Article
- Role of WNT5A receptors FZD5 and RYK in prostate cancer cells.Oncotarget · 2018Article
- Molecular cues on obesity signals, tumor markers and endometrial cancer.Hormone molecular biology and clinical investigation · 2015Review
- Down-regulated expression of Notch signaling molecules in human endometrial cancer.Medical oncology (Northwood, London, England) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CONTEXT AND
objectiveThe Wnt pathway is involved in tumorigenesis of several tissues. For this reason, we proposed to evaluate Wnt gene expression in endometrial cancer type I. DESIGN AND
settingCross-sectional study on materials gathered from the tissue bank of the Department of Pathology, Universidade Federal de São Paulo.
methodsEndometrial specimens were obtained from surgeries performed between 1995 and 2005 at São Paulo Hospital, Universidade Federal de São Paulo. The material was divided into two groups according to tissue type: Group A, atrophic endometrium (n = 15); and Group B, endometrial adenocarcinoma (n = 45). We compared the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and beta-catenin between endometrial cancer type I and atrophic endometrium.
resultsRegarding Wnt1, FZD1 and Wnt5a expression, no significant association was observed between the groups. A significant association was observed between the groups in relation to FZD5 expression (P = 0.001). The proportion of FZD5-positive samples was significantly higher in group A (80.0%) than in group B (31.1%). Regarding the survival curve for FZD5 in group B, we did not find any significant association between atrophic endometrium and endometrial adenocarcinoma. We also did not find any significant association regarding beta-catenin expression (P = 1.000).
conclusionFZD5 is downregulated in endometrial adenocarcinoma, in comparison with atrophic endometrium.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.