ArticlePediatric nephrology (Berlin, Germany)1990
Polypeptide growth factors in metanephric growth and segmental nephron differentiation.
Article in Pediatric nephrology (Berlin, Germany), 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 72 citations in OpenAlex.
- From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review).Molecular medicine reports · 2026Review
- Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate.The Journal of biological chemistry · 2010Article
- Increased expression of EGFR and TGF-alpha in segmental renal dysplasia in duplex kidney.Pediatric surgery international · 2004Article
- Renal cell cultures for the study of growth factor interactions underlying kidney organogenesis.In vitro cellular & developmental biology. Animal · 2001Article
- Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease.The Journal of clinical investigation · 1998Article
- The role of hepatocyte growth factor (HGF) at progressive stages of metanephric development.In vitro cellular & developmental biology. Animal · 1998Article
- Rat metanephric organ culture in terato-embryology.Cell biology and toxicology · 1996Article
- Analysis of WT1 gene expression during mouse nephrogenesis in organ culture.In vitro cellular & developmental biology. Animal · 1996Article
- Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7).Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice.The American journal of pathology · 1996Article
- Transforming growth factor alpha and epidermal growth factor expression in experimental murine polycystic kidney disease.Pediatric nephrology (Berlin, Germany) · 1996Article
- Effects of experimental ureteral obstruction on platelet-derived growth factor-A and type I procollagen expression in fetal metanephric kidneys.Pediatric nephrology (Berlin, Germany) · 1994Article
- Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease.Pediatric nephrology (Berlin, Germany) · 1993Article
- Immunohistochemical localization of transforming growth factor-alpha and epidermal growth factor-receptor in the mesonephros and metanephros of the chicken.Cell and tissue research · 1993Article
- Abnormal sodium pump distribution during renal tubulogenesis in congenital murine polycystic kidney disease.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Insulin-like growth factors I and II are produced in the metanephros and are required for growth and development in vitro.The Journal of cell biology · 1991Article
- Polypeptide growth factors and the kidney: a developmental perspective.Pediatric nephrology (Berlin, Germany) · 1990Review
- Polypeptide growth factors in metanephric growth and segmental nephron differentiation.Pediatric nephrology (Berlin, Germany) · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Although the developing nephron expresses receptors for various polypeptide growth factors, the specific roles of such factors in renal organogenesis are unknown. Therefore, the effects of epidermal growth factor (EGF) (8.2 x 10(-11) M-1.6 x 10(-8) M), multiplication stimulating activity (MSA) (6.6 x 10(-10) M-1.3 x 10(-8) M) and transforming growth factor beta (TGF-beta) (1 x 10(-12) M-1 x 10(-9) M) on organotypic renal growth and segmental nephron differentiation were studied in a serum-free hormone-supplemented, murine metanephric organ culture system. Following culture in control or growth-factor-supplemented medium, explant growth was assessed, and explant growth and differentiation were determined morphometrically in four defined neprhon segments which were identified morphologically or immunohistologically with segment-specific antibodies and/or lectins: glomeruli, proximal tubules, thick ascending limb-early distal tubules, and collecting tubules. Results showed that EGF increased overall renal growth and specific differentiation of distal elements, but retarded differentiation of glomeruli and proximal tubules. EGF also induced hyperplastic cystic malformation in proximal tubules. MSA stimulated explant growth and promoted segmental differentiation of all tubular segments. TGF-beta globally retarded in vitro nephrogenesis. Such data demonstrate that polypeptide growth factors have multiple and often disparate effects on overall renal growth in relation to differentiation of discrete nephron segments and provide insight into the factors which may regulate normal and abnormal renal embryogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.