ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2012
Acute enterocyte adaptation to luminal glucose: a posttranslational mechanism for rapid apical recruitment of the transporter GLUT2.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity.Nutrients · 2021Trial
- Essential oils improve nursery pigs' performance and appetite via modulation of intestinal health and microbiota.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- The inflammatory injury of porcine small intestinal epithelial cells induced by deoxynivalenol is related to the decrease in glucose transport.Journal of animal science · 2024Article
- Metabolism and Health Impacts of Dietary Sugars.Journal of lipid and atherosclerosis · 2022Review
- Resistant starch: Implications of dietary inclusion on gut health and growth in pigs: a review.Journal of animal science and biotechnology · 2021Review
- Article
- Effects of Microbial Fermented Feed on Serum Biochemical Profile, Carcass Traits, Meat Amino Acid and Fatty Acid Profile, and Gut Microbiome Composition of Finishing Pigs.Frontiers in veterinary science · 2021Article
- Review
- The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis.Scientific reports · 2017Article
- Ghrelin Facilitates GLUT2-, SGLT1- and SGLT2-mediated Intestinal Glucose Transport in Goldfish (Carassius auratus).Scientific reports · 2017Article
- Sodium glucose cotransporter SGLT1 as a therapeutic target in diabetes mellitus.Expert opinion on therapeutic targets · 2016Review
- Review
- Oxygen in the regulation of intestinal epithelial transport.The Journal of physiology · 2014Review
- Fructose transporters GLUT5 and GLUT2 expression in adult patients with fructose intolerance.United European gastroenterology journal · 2014Article
- Article
- Lack of functionally active sweet taste receptors in the jejunum in vivo in the rat.The Journal of surgical research · 2013Article
- The role of fructose transporters in diseases linked to excessive fructose intake.The Journal of physiology · 2013Review
- Translocation of transfected GLUT2 to the apical membrane in rat intestinal IEC-6 cells.Digestive diseases and sciences · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGlucose absorption postprandially increases markedly to levels far greater than possible by the classic glucose transporter sodium-glucose cotransporter 1 (SGLT1). HYPOTHESIS: Luminal concentrations of glucose >50 mM lead to rapid, phenotypic, non-genomic adaptations by the enterocyte to recruit another transporter, glucose transporter 2 (GLUT2), to the apical membrane to increase glucose absorption.
methodsIsolated segments of jejunum were perfused in vivo with glucose-containing solutions in anesthetized rats. Carrier-mediated glucose uptake was measured in 10 and 100 mM glucose solutions (n = 6 rats each) with and without selective inhibitors of SGLT1 and GLUT2.
resultsThe mean rate of carrier-mediated glucose uptake increased in rats perfused with 100 mM versus 10 mM glucose to 13.9 ± 2.9 μmol from 2.1 ± 0.1 μmol, respectively (p < 0.0001). Using selective inhibitors, the relative contribution of GLUT2 to glucose absorption was 56% in the 100 mM concentration of glucose compared to the 10 mM concentration (27%; p < 0.01). Passive absorption accounted for 6% of total glucose absorption at 100 mM glucose.
conclusionA small amount of GLUT2 is active at the lesser luminal concentrations of glucose, but when exposed to concentrations of 100 mM, the enterocyte presumably changes its phenotype by recruiting GLUT2 apically to markedly augment glucose absorption.
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