ArticlePediatric nephrology (Berlin, Germany)1990
Treatment of steroid-resistant focal segmental glomerulosclerosis with pulse methylprednisolone and alkylating agents.
Article in Pediatric nephrology (Berlin, Germany), 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 150 citations in OpenAlex.
- Cyclosporine and steroid therapy in children with steroid-resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2009Trial
- Mycophenolate mofetil in steroid/cyclosporine-dependent/resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2005Trial
- Cyclophosphamide does not benefit patients with focal segmental glomerulosclerosis. A report of the International Study of Kidney Disease in Children.Pediatric nephrology (Berlin, Germany) · 1996Trial
- Recurrent nephrotic syndrome after transplantation: early treatment with plasmaphaeresis and cyclophosphamide.Pediatric nephrology (Berlin, Germany) · 1993Trial
- Pulse cyclophosphamide therapy for steroid-resistant focal segmental glomerulosclerosis in children.Annals of Saudi medicineTrial
- Efficacy and Safety of Immunosuppressive Therapy in Primary Focal Segmental Glomerulosclerosis: A Systematic Review and Meta-analysis.Kidney medicine · 2022Article
- Current understandings in treating children with steroid-resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2021Review
- Nephrotic Syndrome in South African Children: Changing Perspectives in the New Millennium.Kidney international reports · 2019Review
- Acute kidney injury in childhood-onset nephrotic syndrome: Incidence and risk factors in hospitalized patients.Kidney research and clinical practice · 2018Article
- Long-term outcome of idiopathic steroid-resistant nephrotic syndrome in children.Pediatric nephrology (Berlin, Germany) · 2016Article
- A predictive model of progressive chronic kidney disease in idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2015Article
- Childhood nephrotic syndrome--current and future therapies.Nature reviews. Nephrology · 2012Review
- Focal segmental glomerulosclerosis and chronic kidney disease in pediatric patients.Advances in chronic kidney disease · 2011Review
- Treatment of steroid-resistant pediatric nephrotic syndrome.Korean journal of pediatrics · 2011Article
- Hereditary nephrotic syndrome: a systematic approach for genetic testing and a review of associated podocyte gene mutations.Pediatric nephrology (Berlin, Germany) · 2010Review
- Primary focal segmental glomerulosclerosis in Egyptian children: a 10-year single-centre experience.Pediatric nephrology (Berlin, Germany) · 2010Article
- Pharmacotherapeutic review and update of idiopathic nephrotic syndrome in children.Pharmacy world & science : PWS · 2010Review
- Experience with tacrolimus in children with steroid-resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2009Article
- Complete remission of nephrotic syndrome in an infant with focal segmental glomerulosclerosis: is it renin-angiotensin blockade?Pediatric nephrology (Berlin, Germany) · 2009Article
- Ponticelli regimen in idiopathic nephrotic syndrome.Indian journal of nephrology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In children, steroid-resistant nephrotic syndrome due to focal segmental glomerulosclerosis (FSGS) is frequently a progressive condition resulting in end-stage renal disease. There have been no reports of effective treatment for this condition. For the past several years, the Pediatric Nephrology services at the University of California, San Diego and Stanford University Schools of Medicine have treated these patients with a protocol involving infusions of high doses of methylprednisolone, often in combination with oral alkylating agents. Twenty-three children have been treated in this manner with a follow-up of 46 +/- 5 months. Twelve of these children are in complete remission. Six have minimal to moderate proteinuria. Four children remain nephrotic. Each of these children has a normal glomerular filtration rate. One child developed chronic renal failure and subsequently died while on dialysis. These results appear significantly better than previous series of children with FSGS. A controlled, multi-center trial of this protocol has been proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.