ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2012
Protective effect of the APOE-e3 allele in Alzheimer's disease.
Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of apolipoprotein E variants on Alzheimer's disease in Latin America: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Causal association of circulating cholesterol levels with dementia: a mendelian randomization meta-analysis.Translational psychiatry · 2020Pooled it
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Trial
- Age at natural menopause, reproductive lifespan and Alzheimer's disease in females: is APOE ε4 the missing link?Frontiers in genetics · 2026Article
- Current Status and Future Perspective of Seoul National University Hospital-Dementia Brain Bank with Concordance of Clinical and Neuropathological Diagnosis.Experimental neurobiology · 2024Article
- Application of CRISPR/Cas9 System in the Treatment of Alzheimer's Disease and Neurodegenerative Diseases.Molecular neurobiology · 2024Review
- Differences in Grey Matter Concentrations and Functional Connectivity between Young Carriers and Non-Carriers of the APOE ε4 Genotype.Journal of clinical medicine · 2024Article
- Insights from a 7-Year Dementia Cohort (VALCODIS): ApoE Genotype Evaluation.Journal of clinical medicine · 2024Article
- An interpretable deep learning framework identifies proteomic drivers of Alzheimer's disease.Frontiers in cell and developmental biology · 2024Article
- Interactive effects of the APOE and BDNF polymorphisms on functional brain connectivity: the Tasmanian Healthy Brain Project.Scientific reports · 2021Article
- The combined risk effect among BIN1, CLU, and APOE genes in Alzheimer's disease.Genetics and molecular biology · 2020Article
- Validating GWAS Variants from Microglial Genes Implicated in Alzheimer's Disease.Journal of molecular neuroscience : MN · 2017Article
- Executive function performance and change in aging is predicted by apolipoprotein E, intensified by catechol-O-methyltransferase and brain-derived neurotrophic factor, and moderated by age and lifestyle.Neurobiology of aging · 2017Article
- Associations between depression, sleep disturbance, and apolipoprotein E in the development of Alzheimer's disease: dementia.International psychogeriatrics · 2016Article
- Association of Alzheimer's Disease With APOE and IL-1α Gene Polymorphisms.American journal of Alzheimer's disease and other dementias · 2015Article
- Association of MTHFR and PICALM polymorphisms with Alzheimer's disease.Molecular biology reports · 2015Article
- Synergistic associations of catechol-O-methyltransferase and brain-derived neurotrophic factor with executive function in aging are selective and modified by apolipoprotein E.Neurobiology of aging · 2015Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although several alleles of susceptibility to Alzheimer's disease (AD) have been studied in the last decades, few polymorphisms have been considered as risk factors for the disease. Among them, the APOE-e4 allele appears to be the major genetic risk factor for the onset of the disease. However, it is important to confirm the potential susceptibility of these genetic variants in different populations in order to establish a genetic profile for the disease in specific communities. This study analyzed the APOE polymorphisms regarding susceptibility to AD in a sample of 264 individuals (primarily Caucasians; 82 cases and 182 controls) in the population from Vitória, ES, Brazil, by PCR restriction fragment length polymorphism (PCR-RFLP) methods. The patients were selected according to clinical criteria for probable AD. Whereas the e4 allele showed statistically significant positive association with susceptibility to AD (OR = 3.01, 95%CI = 1.96-4.61; P < 0.0001), the e2 allele did not. The results of the e4 allele confirm the role of this polymorphism as a risk factor for AD in the sample studied as observed in other populations. Although the e3 allele has been considered neutral in several studies, our results suggest that it acts as a protective factor against AD in the population studied (OR = 0.46, 95%CI = 0.30-0.67; P < 0.0001). This study may provide a new insight into the role of the APOE-e3 allele in the etiology of AD and might help to establish a profile of risk for AD in the population from Vitória, ES.
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