Evidence map›Paper›PMID 22068823›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2012

On the origin of the triplet puzzle of homologies in receptor heteromers: Toll-like receptor triplets in different types of receptors.

Alexander O Tarakanov, Kjell G Fuxe, Dasiel O Borroto-Escuela

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural-glial networks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015
    Review
  2. Article
  3. Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Alexander O TarakanovSt. Petersburg Institute for Informatics and Automation, Russian Academy of Sciences, Saint Petersburg, Russia. tar@iias.spb.su
Kjell G Fuxe
Dasiel O Borroto-Escuela
Karolinska Institutet · SESt. Petersburg Institute for Informatics and Automation · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on our theory, we have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors, which seem to originate from toll-like receptors and appear also as homologies in receptor heteromers. The obtained results strengthen our hypothesis that these triplets may 'guide-and-clasp' receptor-receptor interactions.

Indexed as

Amino Acid SequenceAnimalsHumansMolecular Sequence DataProtein SubunitsReceptor Protein-Tyrosine KinasesReceptors, GABA-AReceptors, G-Protein-CoupledReceptors, NeurotransmitterSignal TransductionToll-Like ReceptorsGABRB1 protein, humanProtein SubunitsReceptor Protein-Tyrosine KinasesReceptors, GABA-AReceptors, G-Protein-CoupledReceptors, NeurotransmitterToll-Like Receptors

Identifiers

PMID22068823
OpenAlexW1978637409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.