ArticleThe American journal of gastroenterology2012
Peroral endoscopic myotomy for the treatment of achalasia: a prospective single center study.
Article in The American journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 133 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Endoscopic Peroral Myotomy for Treatment of Achalasia: Multicenter Study
Endoscopic Peroral Myotomy for Treatment of Achalasia: Pilot Study
Personalized Peroral Endoscopic Myotomy for Achalasia
Endoscopic Versus Laparoscopic Myotomy for Treatment of Idiopathic Achalasia: A Randomized, Controlled Trial
Peroral Endoscopic Remyotomy for Failed Heller Myotomy
Clinical Impact of Peroral Endoscopic Myotomy for Esophageal Achalasia
Endoscopic Esophageal Myotomy for the Treatment of Achalasia
Comparison of Peroral Endoscopic Myotomy (POEM) With Laparoscopic Heller Myotomy (LHM) for Treatment of Achalasia, a Retrospective Multicenter Study
Who cites it
133 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- ACG Clinical Guidelines: Diagnosis and Management of Achalasia.The American journal of gastroenterology · 2020Guideline
- The 2 years' long-term efficacy and safety of peroral endoscopic myotomy for the treatment of achalasia: a systematic review.Journal of cardiothoracic surgery · 2019Pooled it
- Safety and efficacy of POEM for treatment of achalasia: a systematic review of the literature.Surgical endoscopy · 2017Pooled it
- Pooled it
- Surgery or Peroral Esophageal Myotomy for Achalasia: A Systematic Review and Meta-Analysis.Medicine · 2016Pooled it
- Efficacy of peroral endoscopic myotomy (POEM) in the treatment of achalasia: a systematic review and meta-analysis.Surgical endoscopy · 2015Pooled it
- Endoscopy versus radiology in post-procedural monitoring after peroral endoscopic myotomy (POEM).Surgical endoscopy · 2018Trial
- Trial
- Symptomatic and physiologic outcomes one year after peroral esophageal myotomy (POEM) for treatment of achalasia.Surgical endoscopy · 2014Trial
- Peroral endoscopic myotomy for idiopathic achalasia: randomized comparison of water-jet assisted versus conventional dissection technique.Surgical endoscopy · 2014Trial
- Tunneling endoscopic muscularis dissection for subepithelial tumors originating from the muscularis propria of the esophagus and gastric cardia.Surgical endoscopy · 2013Trial
- Tension pneumoperitoneum combined with COFrontiers in medicine · 2026Article
- Article
- Robot-Assisted Heller Myotomy Versus Laparoscopic Heller Myotomy: A Systematic Review and Meta-Analysis.Cureus · 2023Review
- Third-space endoscopy: the final frontier.Gastroenterology report · 2023Review
- Water-jetWorld journal of gastrointestinal endoscopy · 2022Article
- Comparison of fully coated anti-reflux metal stenting and per-oral endoscopic myotomy in patients with achalasia: a propensity score-matched retrospective study.BMC gastroenterology · 2022Article
- Peroral endoscopic longerWorld journal of gastrointestinal surgery · 2022Article
- Durability of per-oral endoscopic myotomy beyond 6 years.Endoscopy international open · 2021Article
- Cardiovascular dynamics during peroral endoscopic myotomy for esophageal achalasia: a prospective observational study using non-invasive finger cuff-derived pulse wave analysis.Journal of clinical monitoring and computing · 2021Observational
73 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesEndoscopic balloon dilatation and laparoscopic myotomy are established treatments for achalasia. Recently, a new endoscopic technique for complete myotomy was described. Herein, we report the results of the first prospective trial of peroral endoscopic myotomy (POEM) in Europe.
methodsPOEM was performed under general anesthesia in 16 patients (male:female (12:4), mean age 45 years, range 26-76). The primary outcome was symptom relief at 3 months, defined as an Eckhard score ≤3. Secondary outcomes were procedure-related adverse events, lower esophageal sphincter (LES) pressure on manometry, reflux symptoms, and medication use before and after POEM.
resultsA 3-month follow-up was completed for all patients. Treatment success (Eckhard score ≤3) was achieved in 94% of cases (mean score pre- vs. post-treatment (8.8 vs. 1.4); P<0.001). Mean LES pressure was 27.2 mm Hg pre-treatment and 11.8 mm Hg post-treatment (P<0.001). No patient developed symptoms of gastro-esophageal reflux after treatment, but one patient was found to have an erosive lesion (LA grade A) on follow-up esophagogastroduodenoscopy. No patient required medication with proton pump inhibitors or antacids after POEM.
conclusionsPOEM is a promising new treatment for achalasia resulting in short-term symptom relief in >90% of cases. Studies evaluating long-term efficacy and comparing POEM with established treatments have been initiated.
Indexed as
Identifiers
22068665What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.