ArticleNature communications2011
Modulation of rod photoreceptor output by HCN1 channels is essential for regular mesopic cone vision.
Article in Nature communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Functional development of photoreceptors in human retinal organoids.Stem cell research & therapy · 2026Article
- Article
- Localization of hyperpolarization-activated cyclic nucleotide-gated channels in the vertebrate retinas across species and their physiological roles.Frontiers in neuroanatomy · 2024Review
- Retinal Dysfunction in a Mouse Model of HCN1 Genetic Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Photoreceptor Ion Channels in Signaling and Disease.Advances in experimental medicine and biology · 2023Article
- Progressively Decreased HCN1 Channels Results in Cone Morphological Defects in Diabetic Retinopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cone-Driven Retinal Responses Are Shaped by Rod But Not Cone HCN1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Use of extended protocols with nonstandard stimuli to characterize rod and cone contributions to the canine electroretinogram.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- Identification of HCN1 as a 14-3-3 client.PloS one · 2022Article
- Review
- Interphotoreceptor coupling: an evolutionary perspective.Pflugers Archiv : European journal of physiology · 2021Review
- Light responses of mammalian cones.Pflugers Archiv : European journal of physiology · 2021Review
- Electrophysiologic Characterization of Developing Human Embryonic Stem Cell-Derived Photoreceptor Precursors.Investigative ophthalmology & visual science · 2020Article
- A Comparison of the Primary Sensory Neurons Used in Olfaction and Vision.Frontiers in cellular neuroscience · 2020Review
- Sex-related differences in the progressive retinal degeneration of the rd10 mouse.Experimental eye research · 2019Article
- Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium.PloS one · 2019Article
- Article
- MiR-211 is essential for adult cone photoreceptor maintenance and visual function.Scientific reports · 2017Article
- Test-retest reliability of scotopic full-field electroretinograms in rabbits.Documenta ophthalmologica. Advances in ophthalmology · 2017Article
- A novel mechanism of cone photoreceptor adaptation.PLoS biology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal photoreceptors permit visual perception over a wide range of lighting conditions. Rods work best in dim, and cones in bright environments, with considerable functional overlap at intermediate (mesopic) light levels. At many sites in the outer and inner retina where rod and cone signals interact, gap junctions, particularly those containing Connexin36, have been identified. However, little is known about the dynamic processes associated with the convergence of rod and cone system signals into ON- and OFF-pathways. Here we show that proper cone vision under mesopic conditions requires rapid adaptational feedback modulation of rod output via hyperpolarization-activated and cyclic nucleotide-gated channels 1. When these channels are absent, sustained rod responses following bright light exposure saturate the retinal network, resulting in a loss of downstream cone signalling. By specific genetic and pharmacological ablation of key signal processing components, regular cone signalling can be restored, thereby identifying the sites involved in functional rod-cone interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.