ArticleNature communications2011
Extrasynaptic vesicle recycling in mature hippocampal neurons.
Article in Nature communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed.
- Mesenchymal stromal cell secretome-induced synaptogenesis is mediated by thrombospondin-1.iScience · 2025Article
- PHluorin-conjugated secondary nanobodies as a tool for measuring synaptic vesicle exocytosis and endocytosis.Scientific reports · 2025Article
- Axonal neurotransmitter release in the regulation of myelination.Bioscience reports · 2024Review
- Elevated amyloid beta disrupts the nanoscale organization and function of synaptic vesicle pools in hippocampal neurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Nanoscale molecular architecture controls calcium diffusion and ER replenishment in dendritic spines.Science advances · 2021Article
- Clathrin packets move in slow axonal transport and deliver functional payloads to synapses.Neuron · 2021Article
- Misfolded amyloid-β-42 impairs the endosomal-lysosomal pathway.Cellular and molecular life sciences : CMLS · 2020Article
- A Human Induced Pluripotent Stem Cell-Derived Isogenic Model of Huntington's Disease Based on Neuronal Cells Has Several Relevant Phenotypic Abnormalities.Journal of personalized medicine · 2020Article
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- Dedicated Setup for the Photoconversion of Fluorescent Dyes for Functional Electron Microscopy.Frontiers in cellular neuroscience · 2019Article
- Postnatal Restriction of Activity-Induced CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases.Cells · 2018Review
- Article
- The complexities underlying age-related macular degeneration: could amyloid beta play an important role?Neural regeneration research · 2017Review
- The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2).Experimental eye research · 2016Article
- Two-photon fluorescence lifetime imaging of primed SNARE complexes in presynaptic terminals and β cells.Nature communications · 2015Article
- Ultrastructural and functional fate of recycled vesicles in hippocampal synapses.Nature communications · 2015Article
- Alzheimer's disease-related amyloid-β induces synaptotoxicity in human iPS cell-derived neurons.Cell death & disease · 2015Article
- Ultrastructural readout of functional synaptic vesicle pools in hippocampal slices based on FM dye labeling and photoconversion.Nature protocols · 2014Article
- Presynaptic ultrastructural plasticity along CA3→CA1 axons during long-term potentiation in mature hippocampus.The Journal of comparative neurology · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Fast neuronal signalling relies on highly regulated vesicle fusion and recycling at specialized presynaptic terminals. Recently, examples of non-classical neurotransmission have also been reported, where fusion of vesicles can occur at sites remote from conventional synapses. This has potentially broad biological implications, but the underlying mechanisms are not well established. Here we show that a complete vesicle recycling pathway can occur at discrete axonal sites in mature hippocampal neurons and that extrasynaptic fusion is a robust feature of native tissue. We demonstrate that laterally mobile vesicle clusters trafficking between synaptic terminals become transiently stabilized by evoked action potentials and undergo complete but delayed Ca(2+)-dependent fusion along axons. This fusion is associated with dynamic actin accumulation and, subsequently, vesicles can be locally recycled, re-acidified and re-used. Immunofluorescence and ultrastructural work demonstrates that extrasynaptic fusion sites can have apposed postsynaptic specializations, suggesting that mobile vesicle recycling may underlie highly dynamic neuron-neuron communication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.