ArticleWorld journal of urology2013
Low serum testosterone levels are predictive of prostate cancer.
Article in World journal of urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Role of Vitamin B₆ in Testosterone Synthesis.The world journal of men's health · 2026Review
- Role of Lipoic Acid in Testosterone Production in Males.The world journal of men's health · 2025Review
- Testosterone Nanoemulsion Prevents Prostate Cancer: PC-3 and LNCaP Cell Viability In Vitro.International journal of molecular sciences · 2024Article
- Article
- The role of testosterone in men's health: is it time for a new approach?International urology and nephrology · 2022Review
- Do prostate-specific antigen parameters have a similar role in predicting prostate cancer regardless of serum testosterone levels in men with gray-zone prostate-specific antigen levels?Translational andrology and urology · 2022Article
- The androgen receptor-lncRNASAT1-AKT-p15 axis mediates androgen-induced cellular senescence in prostate cancer cells.Oncogene · 2022Article
- Endogenous testosterone as a predictor of prostate growing disorders in the aging male.International urology and nephrology · 2021Article
- Endocrinology of the Aging Prostate: Current Concepts.Frontiers in endocrinology · 2021Review
- Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer.Cancers · 2020Review
- Treatment Stratification of Patients with Metastatic Castration-Resistant Prostate Cancer by Machine Learning.iScience · 2020Article
- Association Between Serum Testosterone and Serum PSA Among Men With and Without Partial Androgen Deficiency.Indian journal of clinical biochemistry : IJCB · 2020Article
- Changes in the levels of testosterone profile over time in relation to clinical parameters in a cohort of patients with prostate cancer managed by active surveillance.World journal of urology · 2018Article
- The Role of Testosterone Therapy in the Setting of Prostate Cancer.Current urology reports · 2018Review
- Association between age-related reductions in testosterone and risk of prostate cancer-An analysis of patients' data with prostatic diseases.International journal of cancer · 2017Article
- Preoperative Plasma Levels of Total Testosterone Associated with High Grade Pathology-Detected Prostate Cancer: Preliminary Results of a Prospective Study in a Contemporary Cohort of Patients.Current urology · 2017Article
- Endogenous and exogenous testosterone and prostate cancer: decreased-, increased- or null-risk?Translational andrology and urology · 2017Review
- Testosterone therapy and prostate cancer.Translational andrology and urology · 2016Review
- Testosterone Therapy Among Prostate Cancer Survivors.Sexual medicine reviews · 2016Review
- Testosterone and prostate cancer: an evidence-based review of pathogenesis and oncologic risk.Therapeutic advances in urology · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough hormones play fundamental roles in prostate growth, their clinical significance is not completely clear. Aims of present study were to assess whether testosterone and serum sex hormone levels are predictors of benign prostatic hyperplasia (BPH) or prostate cancer (PC) and to verify whether prostate cancer is associated with low testosterone levels, and to test association between testosterone levels and known prognostic factors in prostate cancer.
methodsIn 206 consecutive patients with benign prostatic hyperplasia or prostate cancer testosterone, follicle-stimulating hormone, luteinizing hormone and prolactin levels were tested and correlated with disease. In patients with prostate cancer, hormone levels were also correlated with known prognostic factors. Predictive value was assessed for age, prostate-specific antigen (PSA), PSA ratio, PSA density, prostate volume and serum sex hormone levels using multiple logistic regression analysis and receiver operating characteristic curves.
resultsConsidering sex hormones, only testosterone levels were significantly lower in patients with prostate cancer than those with BPH; testosterone levels appear to be independent predictor of prostate cancer, enhancing predictive accuracy for BPH and PC. Testosterone levels do not seem to be associated with known clinical prognostic factors.
conclusionsThis study supports experimental findings that testosterone levels are predictor of prostate cancer and that prostate cancer is frequently associated with low testosterone levels. In the diagnostic work-up for prostate cancer, adding testosterone determination to PSA test may improve predictive accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.