ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2012
Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Circulating osteocalcin as a bone-derived hormone is inversely correlated with body fat in patients with type 1 diabetes.PloS one · 2019Trial
- Higher osteocalcin levels are associated with preserved β-cell function in early-established type 1 diabetes.Journal of endocrinological investigation · 2026Article
- Article
- The Role of Bone-Derived Hormones in Glucose Metabolism, Diabetic Kidney Disease, and Cardiovascular Disorders.International journal of molecular sciences · 2022Review
- TGFβ Regulation of Perilacunar/Canalicular Remodeling Is Sexually Dimorphic.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Serum C-peptide and osteocalcin levels in children with recently diagnosed diabetes.Endocrinology, diabetes & metabolism · 2020Article
- The Endocrine Role of Bone in Cardiometabolic Health.Current nutrition reports · 2019Review
- Diabetes pharmacotherapy and effects on the musculoskeletal system.Diabetes/metabolism research and reviews · 2019Review
- Undercarboxylated Osteocalcin: Experimental and Human Evidence for a Role in Glucose Homeostasis and Muscle Regulation of Insulin Sensitivity.Nutrients · 2018Review
- Association between serum osteocalcin and glucose/lipid metabolism in Chinese Han and Uygur populations with type 2 diabetes mellitus in Xinjiang: two cross-sectional studies.Lipids in health and disease · 2017Article
- Relationships between Bone Turnover and Energy Metabolism.Journal of diabetes research · 2017Review
- Pleotropic Acute and Chronic Effects of Leptin to Reverse Type 1 Diabetes.Postdoc journal : a journal of postdoctoral research and postdoctoral affairs · 2017Article
- Epidemiology of Skeletal Health in Type 1 Diabetes.Current osteoporosis reports · 2016Review
- Osteocalcin levels are inversely associated with Hba1c and BMI in adult subjects with long-standing type 1 diabetes.Journal of endocrinological investigation · 2014Article
- PHEX mimetic (SPR4-peptide) corrects and improves HYP and wild type mice energy-metabolism.PloS one · 2014Article
- The alliance of mesenchymal stem cells, bone, and diabetes.International journal of endocrinology · 2014Review
- Osteo-promoting effects of insulin-like growth factor I (IGF-I) in a mouse model of type 1 diabetes.Bone · 2013Article
- The role of vitamin D in the metabolic homeostasis of diabetic bone.Clinical reviews in bone and mineral metabolism · 2013Article
- In vivo analysis of the contribution of bone resorption to the control of glucose metabolism in mice.Molecular metabolism · 2013Article
- Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes.PloS one · 2013Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledTo determine whether undercarboxylated osteocalcin (UC-OC) or gamma-carboxyglutamic-carboxylated-type osteocalcin (GLA-OC) concentrations deviate from normal in type 1 diabetes (T1D), serum levels were compared between 115 subjects with T1D and 55 age-matched healthy controls. UC-OC and GLA-OC concentrations were similar between groups; however, in T1D, UC-OC correlated positively with markers of insulin exposure, either endogenously produced or exogenously administered.
introductionA study was conducted to determine whether dysregulation of circulating concentrations of UC-OC or GLA-OC occurs in patients with type 1 diabetes, a condition of insulin deficiency without insulin resistance.
methodsWe measured serum concentrations of UC-OC and GLA-OC in 115 subjects with T1D, ages 14-40 years, and in 55 age-matched healthy control subjects. Relationships between UC-OC and GLA-OC concentrations and patient characteristics (gender and age), indices of glycemic control (hemoglobin A1c (HbA1c), fasting plasma glucose, C-peptide concentration, 3-day average glucose measured by a continuous glucose sensor, total daily insulin dose) and circulating indices of skeletal homeostasis (total calcium, 25-OH vitamin D, parathyroid hormone, insulin-like growth factor 1 (IGF-1), type 1 collagen degradation fragments (CTX), adiponectin, leptin) were examined. Between group differences in the concentrations of UC-OC and GLA-OC were the main outcome measures.
resultsAlthough adiponectin levels were higher in the T1D group, between-group comparisons did not reveal statistically significant differences in concentration of UC-OC, GLA-OC, CTX or leptin between the T1D and control populations. Instead, by multivariate regression modeling, UC-OC was correlated with younger age (p < 0.001), higher CTX (p < 0.001), lower HbA1c (p = 0.013), and higher IGF-1 (p = 0.086). Moreover, within the T1D subgroup, UC-OC was positively correlated with C-peptide/glucose ratio (reflecting endogenous insulin secretion), with IGF-1 (reflecting intra-portal insulin sufficiency), and with total daily insulin dose.
conclusionsIn T1D, UC-OC appears to correlate positively with markers of insulin exposure, either endogenously produced or exogenously administered.
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