SynthesisCirculation. Cardiovascular genetics2012
Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium.
Synthesis in Circulation. Cardiovascular genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Arterial Stiffness and Decline in Kidney Function.Clinical journal of the American Society of Nephrology : CJASN · 2015Pooled it
- Overlap between common genetic polymorphisms underpinning kidney traits and cardiovascular disease phenotypes: the CKDGen consortium.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2013Pooled it
- A gene-centric study of common carotid artery remodelling.Atherosclerosis · 2013Pooled it
- The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness.Scientific reports · 2018Trial
- Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.The Journal of clinical investigation · 2017Trial
- Development and Validation of the AI-HeartAge Model in Framingham and UK Biobank.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Glucose-6-Phosphate Dehydrogenase Modifies the Impact of Glucose on Arterial Aging in A Sex-Specific Manner.Journal of the American Heart Association · 2026Article
- Article
- [Genotype-environment interaction on arterial stiffness: A pedigree-based study].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Aging of the Arterial System.International journal of molecular sciences · 2023Review
- Genetic and biomarker modulation of arterial stiffness change in the SardiNIA population cohort.Frontiers in epidemiology · 2023Article
- Collagen type IV as the link between arterial stiffness and dementia.American journal of translational research · 2023Review
- Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction.Arteriosclerosis, thrombosis, and vascular biology · 2022Observational
- Longitudinal genome-wide DNA methylation changes in response to kidney failure replacement therapy.Scientific reports · 2022Article
- BCL11B Regulates Arterial Stiffness and Related Target Organ Damage.Circulation research · 2021Article
- Genetic aetiology of blood pressure relates to aortic stiffness with bi-directional causality: evidence from heritability, blood pressure polymorphisms, and Mendelian randomization.European heart journal · 2020Article
- Uses of Arterial Stiffness in Clinical Practice.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System.Frontiers in cell and developmental biology · 2020Review
- Article
- Genome-wide linkage analysis of carotid artery traits in exceptionally long-lived families.Atherosclerosis · 2019Article
Corrections and comments
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Authors and funding
75 authors at 17 institutions in 11 countries.
Funding
Abstract
backgroundCarotid-femoral pulse wave velocity (CFPWV) is a heritable measure of aortic stiffness that is strongly associated with increased risk for major cardiovascular disease events. METHODS AND
resultsWe conducted a meta-analysis of genome-wide association data in 9 community-based European ancestry cohorts consisting of 20 634 participants. Results were replicated in 2 additional European ancestry cohorts involving 5306 participants. Based on a preliminary analysis of 6 cohorts, we identified a locus on chromosome 14 in the 3'-BCL11B gene desert that is associated with CFPWV (rs7152623, minor allele frequency=0.42, β=-0.075±0.012 SD/allele, P=2.8×10(-10); replication β=-0.086±0.020 SD/allele, P=1.4×10(-6)). Combined results for rs7152623 from 11 cohorts gave β=-0.076±0.010 SD/allele, P=3.1×10(-15). The association persisted when adjusted for mean arterial pressure (β=-0.060±0.009 SD/allele, P=1.0×10(-11)). Results were consistent in younger (<55 years, 6 cohorts, n=13 914, β=-0.081±0.014 SD/allele, P=2.3×10(-9)) and older (9 cohorts, n=12 026, β=-0.061±0.014 SD/allele, P=9.4×10(-6)) participants. In separate meta-analyses, the locus was associated with increased risk for coronary artery disease (hazard ratio=1.05; confidence interval=1.02-1.08; P=0.0013) and heart failure (hazard ratio=1.10, CI=1.03-1.16, P=0.004).
conclusionsCommon genetic variation in a locus in the BCL11B gene desert that is thought to harbor 1 or more gene enhancers is associated with higher CFPWV and increased risk for cardiovascular disease. Elucidation of the role this novel locus plays in aortic stiffness may facilitate development of therapeutic interventions that limit aortic stiffening and related cardiovascular disease events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.