Evidence map›Paper›PMID 22068286›Full record

SynthesisCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2012

Exercise effects on depressive symptoms in cancer survivors: a systematic review and meta-analysis.

Lynette L Craft, Erik H Vaniterson, Irene B Helenowski, Alfred W Rademaker, Kerry S Courneya

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 21 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 21 syntheses or guidelines pooled it, 272 citations in OpenAlex.

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  15. Ameliorative effects of Tai Chi on cancer-related fatigue: a meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
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  16. Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018
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  18. Determinants of exercise adherence and maintenance among cancer survivors: a systematic review.The international journal of behavioral nutrition and physical activity · 2014
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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Lynette L CraftDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N. Lake Shore Drive, Suite 1400, Chicago, IL 60611, USA. lynette-craft@northwestern.edu
Erik H Vaniterson
Irene B Helenowski
Alfred W Rademaker
Kerry S Courneya
University of Alberta · CANorthwestern University · US

Funding

Intermittent Exercise and Symptom Management in Breast Cancer SurvivorsK07CA134936 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CRAFT, LYNETTE L · 2009 to 2011
$397k
NCI NIH HHS 1K07CA134936-01A1NCI NIH HHS K07 CA134936
6 · The paper itself

Abstract

backgroundDepression is a distressing side effect of cancer and its treatment. In the general population, exercise is an effective antidepressant.

objectiveWe conducted a systematic review and meta-analysis to determine the antidepressant effect of exercise in cancer survivors. DATA SOURCES: In May 2011, we searched MEDLINE, PsycInfo, EMBASE, CINAHL, CDSR, CENTRAL, AMED, Biosis Previews, and Sport Discus and citations from relevant articles and reviews. STUDY ELIGIBILITY CRITERIA: We included randomized controlled trials (RCT) comparing exercise interventions with usual care in cancer survivors, using a self-report inventory or clinician rating to assess depressive symptoms, and reporting symptoms pre- and postintervention. STUDY APPRAISAL: Around 7,042 study titles were identified and screened, with 15 RCTs included. SYNTHESIS

methodsEffect sizes (ES) were reported as mean change scores. The Q test was conducted to evaluate heterogeneity of ES. Potential moderator variables were evaluated with examination of scatter plots and Wilcoxon rank-sum or Kruskal-Wallis tests.

resultsThe overall ES, under a random-effects model, was -0.22 (confidence interval, -0.43 to -0.09; P = 0.04). Significant moderating variables (ps < 0.05) were exercise location, exercise supervision, and exercise duration. LIMITATIONS: Only one study identified depression as the primary endpoint.

conclusionsExercise has modest positive effects on depressive symptoms with larger effects for programs that were supervised or partially supervised, not conducted at home, and at least 30 minutes in duration. IMPACT: Our results complement other studies showing that exercise is associated with reduced pain and fatigue and with improvements in quality of life among cancer survivors.

Indexed as

DepressionExerciseHumansNeoplasmsPhysical FitnessQuality of LifeSurvivors

Identifiers

PMID22068286
PMCPMC3253916
OpenAlexW2001933461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.