ArticleThe American journal of pathology2012
Apelin is required for non-neovascular remodeling in the retina.
Article in The American journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Retinopathy of Prematurity and MicroRNAs.Biomedicines · 2025Review
- Targeting circRNA-MAP4K2 for the treatment of diabetes-induced retinal vascular dysfunction.Aging · 2022Article
- Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth.Nature cardiovascular research · 2022Article
- Article
- Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction.The Journal of clinical investigation · 2020Article
- The Role of Apelin/APJ in a Mouse Model of Oxygen-induced Retinopathy.Investigative ophthalmology & visual science · 2020Article
- Retinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach.BMC ophthalmology · 2020Article
- What is normal? Apelin and VEGFA, drivers of tumor vessel abnormality.EMBO molecular medicine · 2019Article
- Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin.Frontiers in immunology · 2018Article
- Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis.Communications biology · 2018Article
- An apelin receptor antagonist prevents pathological retinal angiogenesis with ischemic retinopathy in mice.Scientific reports · 2017Article
- Expression of neonatal Fc receptor in the eye.Investigative ophthalmology & visual science · 2014Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Retinal pathologies are frequently accompanied by retinal vascular responses, including the formation of new vessels by angiogenesis (neovascularization). Pathological vascular changes may also include less well characterized traits of vascular remodeling that are non-neovascular, such as vessel pruning and the emergence of dilated and tortuous vessel phenotypes (telangiectasis). The molecular mechanisms underlying neovascular growth versus non-neovascular remodeling are poorly understood. We therefore undertook to identify novel regulators of non-neovascular remodeling in the retina by using the dystrophic Royal College of Surgeons (RCS) rat and the retinal dystrophy 1 (RD1) mouse, both of which display pronounced non-neovascular remodeling. Gene expression profiling of isolated retinal vessels from these mutant rodent models and wild-type controls revealed 60 differentially expressed genes. These included the genes for apelin (Apln) and for its receptor (Aplnr), both of which were strongly up-regulated in the mutants. Crossing RD1 mice into an Apln-null background substantially reduced vascular telangiectasia. In contrast, Apln gene deletion had no effect in two models of neovascular pathology [laser-induced choroidal neovascularization and the very low density lipoprotein receptor (Vldlr)-knockout mouse]. These findings suggest that in these models apelin has minimal effect on sprouting retinal angiogenesis, but contributes significantly to pathogenic non-neovascular remodeling.
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