ArticleRespiratory physiology & neurobiology2012
Age and sex differences in the ventilatory response to hypoxia and hypercapnia in awake neonatal, pre-pubertal and young adult rats.
Article in Respiratory physiology & neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Sex Differences in the Effects of Etonogestrel on Respiratory Recovery in an In Vivo Rat Model of Central Chemoreflex Impairment.Acta physiologica (Oxford, England) · 2026Article
- ASIC1a channels in the locus coeruleus mediate hypercapnic acidosis detection and COPsychopharmacology · 2026Article
- Article
- Investigating genetic variants in microRNA regulators of Neurokinin-1 receptor in sudden infant death syndrome.Acta paediatrica (Oslo, Norway : 1992) · 2023Article
- Etonogestrel Administration Reduces the Expression of PHOX2B and Its Target Genes in the Solitary Tract Nucleus.International journal of molecular sciences · 2022Article
- Seasonality and Sex-Biased Fluctuation of Birth Weight in Tibetan Populations.Phenomics (Cham, Switzerland) · 2022Article
- Conditional loss of Engrailed1/2 in Atoh1-derived excitatory cerebellar nuclear neurons impairs eupneic respiration in mice.Genes, brain, and behavior · 2022Article
- The ventilatory response to hypoxia is blunted in some preterm infants during the second year of life.Frontiers in pediatrics · 2022Article
- Spinal muscular atrophy: Broad disease spectrum and sex-specific phenotypes.Biochimica et biophysica acta. Molecular basis of disease · 2021Review
- Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics.Biomedicines · 2020Review
- Mechanisms underlying a critical period of respiratory development in the rat.Respiratory physiology & neurobiology · 2019Review
- Brainstem catecholaminergic neurones and breathing control during postnatal development in male and female rats.The Journal of physiology · 2018Article
- Saline as a vehicle control does not alter ventilation in male CD-1 mice.Physiological reports · 2018Article
- Article
- Coordinated Respiratory Motor Activity in Nerves Innervating the Upper Airway Muscles in Rats.PloS one · 2016Article
- Abrupt changes in pentobarbital sensitivity in preBötzinger complex region, hypoglossal motor nucleus, nucleus tractus solitarius, and cortex during rat transitional period (P10-P15).Respiratory physiology & neurobiology · 2015Article
- The physiological determinants of sudden infant death syndrome.Respiratory physiology & neurobiology · 2013Review
- Gender considerations in ventilatory and metabolic development in rats: special emphasis on the critical period.Respiratory physiology & neurobiology · 2013Article
- Carotid chemoreceptor development in mice.Respiratory physiology & neurobiology · 2013Review
- Peripheral-central chemoreceptor interaction and the significance of a critical period in the development of respiratory control.Respiratory physiology & neurobiology · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
There is evidence for a "sensitive period" in respiratory development in rats around postnatal age (P) 12-13d. Little is known about sex differences during that time. The purpose of this study was to assess the effect of sex on breathing development, specifically around the "sensitive period". We used whole-body plethysmography to study breathing in normoxic, hypoxic and hypercapnic gases in non-anesthetized male and female neonatal rats from P10 to P15, juvenile (P30) and young adult (P90) rats. Compared to other neonatal ages, P12-13 male rats had significantly lower ventilation during normoxia, hypoxia, and hypercapnia. Compared to age-matched females, P12-13 male rats had lower ventilation in normoxia and hypoxia and a lower O(2) saturation during hypoxia. Circulating estradiol was greater in P12-13 male vs. female rats. Estradiol and ventilatory responses to hypoxia and hypercapnia were negatively correlated in neonatal male, but not female rats. Our results suggest that P10-15 includes a critical developmental period in male but not female rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.