ReviewBrain : a journal of neurology2012
Neurological diseases and pain.
Review in Brain : a journal of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 1 synthesis or guideline pooled it, 270 citations in OpenAlex.
- Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.Brain imaging and behavior · 2021Pooled it
- 20-kHz alternating current stimulation: effects on motor and somatosensory thresholds.Journal of neuroengineering and rehabilitation · 2020Trial
- Identification of discrete functional subregions of the human periaqueductal gray.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CBPsychopharmacology · 2026Article
- Evolving Paradigms in Cancer Pain Management: From Opioid-Centric Care to Multimodal and Personalized Strategies.Cancers · 2026Review
- How to interpret low-dose valacyclovir for postherpetic neuralgia in the Zoster Eye Disease Study-a randomized clinical trial.Annals of translational medicine · 2026Article
- [Effects of spinal cord stimulation implantation on heart rate variability in patients with postherpetic neuralgia].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- M232R Familial Creutzfeldt-Jacob Disease Challenging to Diagnose Due to the Absence of Characteristic Laboratory Findings.Internal medicine (Tokyo, Japan) · 2026Article
- Home use of low-intensity transcranial electrical stimulation in clinical practice: an IFCN handbook chapter.Clinical neurophysiology practice · 2026Review
- Neuroimaging epicenters and the related neurobiological signatures in patients with postherpetic neuralgia.The journal of headache and pain · 2025Article
- The Silent Cognitive Burden of Chronic Pain: Protocol for an AI-Enhanced Living Dose-Response Bayesian Meta-Analysis.Journal of clinical medicine · 2025Article
- Changes in multimorbidity burden and their impact on patient and healthcare outcomes in people with HIV over a 3-5-year period.AIDS (London, England) · 2025Article
- Assistive Technologies for Individuals with a Disability from a Neurological Condition: A Narrative Review on the Multimodal Integration.Healthcare (Basel, Switzerland) · 2025Review
- Management of post-arthroplasty pain: a narrative review of emerging interventional treatments.Pain management · 2025Review
- Effectiveness of Lee Silverman Voice Treatment (LSVT)-BIG for Neurological Diseases Other than Parkinson's Disease: Mini Review.Brain sciences · 2025Review
- Polyphenols as Wnt/β-catenin pathway modulators: A promising strategy in clinical neurodegeneration.Animal models and experimental medicine · 2025Review
- Pseudogout Localized to the Pubic Symphysis.Internal medicine (Tokyo, Japan) · 2025Article
- Coping with pain among adults with chronic tic disorders.Frontiers in psychology · 2025Article
- From Skin and Gut to the Brain: The Infectious Journey of the Human Commensal Fungus Malassezia and Its Neurological Consequences.Molecular neurobiology · 2025Review
- Pathogenic synergy: dysfunctional mitochondria and neuroinflammation in neurodegenerative diseases associated with aging.Frontiers in aging · 2025Review
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Chronic pain is a frequent component of many neurological disorders, affecting 20-40% of patients for many primary neurological diseases. These diseases result from a wide range of pathophysiologies including traumatic injury to the central nervous system, neurodegeneration and neuroinflammation, and exploring the aetiology of pain in these disorders is an opportunity to achieve new insight into pain processing. Whether pain originates in the central or peripheral nervous system, it frequently becomes centralized through maladaptive responses within the central nervous system that can profoundly alter brain systems and thereby behaviour (e.g. depression). Chronic pain should thus be considered a brain disease in which alterations in neural networks affect multiple aspects of brain function, structure and chemistry. The study and treatment of this disease is greatly complicated by the lack of objective measures for either the symptoms or the underlying mechanisms of chronic pain. In pain associated with neurological disease, it is sometimes difficult to obtain even a subjective evaluation of pain, as is the case for patients in a vegetative state or end-stage Alzheimer's disease. It is critical that neurologists become more involved in chronic pain treatment and research (already significant in the fields of migraine and peripheral neuropathies). To achieve this goal, greater efforts are needed to enhance training for neurologists in pain treatment and promote greater interest in the field. This review describes examples of pain in different neurological diseases including primary neurological pain conditions, discusses the therapeutic potential of brain-targeted therapies and highlights the need for objective measures of pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.