Evidence map›Paper›PMID 22067111›Full record

ArticleACS nano2011

Multistrand RNA secondary structure prediction and nanostructure design including pseudoknots.

Eckart Bindewald, Kirill Afonin, Luc Jaeger, Bruce A Shapiro

Abstract read
In one paragraph

Article in ACS nano, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Review
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  10. Tuning the size, shape and structure of RNA nanoparticles for favorable cancer targeting and immunostimulation.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020
    Review
  11. Review
  12. Article
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  15. Review
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  18. Versatile RNA tetra-U helix linking motif as a toolkit for nucleic acid nanotechnology.Nanomedicine : nanotechnology, biology, and medicine · 2017
    Article
  19. Review
  20. Computational Generation of RNA Nanorings.Methods in molecular biology (Clifton, N.J.) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eckart BindewaldBasic Science Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States.
Kirill Afonin
Luc Jaeger
Bruce A Shapiro

Funding

Computational RNA NanodesignZIABC011061 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SHAPIRO, BRUCE · 2009 to 2021
$12.3M
Exploring the RNA syntax for engineering therapeutic RNA-based nano-factoriesR01GM079604 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI JAEGER, LUC · 2007 to 2011
$1.7M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA BC011061NCI NIH HHS HHSN261200800001ENIGMS NIH HHS R01 GM079604
6 · The paper itself

Abstract

We are presenting NanoFolder, a method for the prediction of the base pairing of potentially pseudoknotted multistrand RNA nanostructures. We show that the method outperforms several other structure prediction methods when applied to RNA complexes with non-nested base pairs. We extended this secondary structure prediction capability to allow RNA sequence design. Using native PAGE, we experimentally confirm that four in silico designed RNA strands corresponding to a triangular RNA structure form the expected stable complex.

Indexed as

Base PairingModels, ChemicalModels, MolecularBase SequenceComputer SimulationMolecular Sequence DataNanostructuresNucleic Acid ConformationParticle SizeRNASurface PropertiesRNA

Identifiers

PMID22067111
PMCPMC3263976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.