ArticleAssay and drug development technologies2012
Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors.
Article in Assay and drug development technologies, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Agonist activation to open the Gα subunit of the GPCR-G protein precoupled complex defines functional agonist activation of TAS2R5.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Label-Free Investigations on the G Protein Dependent Signaling Pathways of Histamine Receptors.International journal of molecular sciences · 2021Article
- Role of PKC in the Regulation of the Human Kidney Chloride Channel ClC-Ka.Scientific reports · 2020Article
- Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies.Pharmacology research & perspectives · 2018Article
- Article
- A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.Scientific reports · 2016Article
- Sphere-derived tumor cells exhibit impaired metastasis by a host-mediated quiescent phenotype.Oncotarget · 2015Article
- Purinergic signalling in the kidney in health and disease.Purinergic signalling · 2014Review
- Dynamic mass redistribution analysis of endogenous β-adrenergic receptor signaling in neonatal rat cardiac fibroblasts.Pharmacology research & perspectives · 2014Article
- Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion.Sensors and actuators. B, Chemical · 2013Article
- Microplate-compatible total internal reflection fluorescence microscopy for receptor pharmacology.Applied physics letters · 2013Article
- Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.BMC pharmacology & toxicology · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Interactions with extracellular matrices (ECM) shape the signaling and functions of many types of cells and receptors, and distinct ECM coatings have been used in a wide range of substrates for drug discovery processes. Here, we investigate the influence of ECM protein coatings on the signaling of endogenous purinergic 2Y (P2Y) receptors in human embryonic kidney HEK293 cells using dynamic mass redistribution (DMR) assays enabled by label-free optical biosensor. Results showed that ECM proteins had significant impacts on the DMR characteristics, potency, and efficacy of seven P2Y agonists. This study documents the importance of surface chemistry in regulating receptor signaling.
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Registered trials
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