ArticleJournal of the American Chemical Society2011
The fast and the slow: folding and trapping of λ6-85.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Chemical interactions modulate λProtein science : a publication of the Protein Society · 2023Article
- Competition of individual domain folding with inter-domain interaction in WW domain engineered repeat proteins.Physical chemistry chemical physics : PCCP · 2019Article
- The Surface of Protein λBiochemistry · 2017Article
- Cooperative folding near the downhill limit determined with amino acid resolution by hydrogen exchange.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Fast-folding proteins under stress.Cellular and molecular life sciences : CMLS · 2015Review
- Mapping fast protein folding with multiple-site fluorescent probes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Dominance of misfolded intermediates in the dynamics of α-helix folding.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Dynamical phase transitions reveal amyloid-like states on protein folding landscapes.Biophysical journal · 2014Article
- Fast protein folding kinetics.Quarterly reviews of biophysics · 2014Review
- Dodine as a protein denaturant: the best of two worlds?The journal of physical chemistry. B · 2013Article
- Inclusion of persistence length-based secondary structure in replica field theoretic models of heteropolymer freezing.The Journal of chemical physics · 2013Article
- Misplaced helix slows down ultrafast pressure-jump protein folding.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Emergence of glass-like behavior in Markov state models of protein folding dynamics.Journal of the American Chemical Society · 2013Article
- Microsecond folding experiments and simulations: a match is made.Physical chemistry chemical physics : PCCP · 2013Article
- Folding of a heterogeneous β-hairpin peptide from temperature-jump 2D IR spectroscopy.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- To milliseconds and beyond: challenges in the simulation of protein folding.Current opinion in structural biology · 2013Review
- Fast photochemical oxidation of proteins and mass spectrometry follow submillisecond protein folding at the amino-acid level.Journal of the American Chemical Society · 2012Article
- Structural Characterization of λ-Repressor Folding from All-Atom Molecular Dynamics Simulations.The journal of physical chemistry letters · 2012Article
- Crowding effects on the small, fast-folding protein lambda6-85.Faraday discussions · 2012Article
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Authors and funding
2 authors.
Funding
Abstract
Molecular dynamics simulations combining many microsecond trajectories have recently predicted that a very fast folding protein like lambda repressor fragment λ(6-85) D14A could have a slow millisecond kinetic phase. We investigated this possibility by detecting temperature-jump relaxation to 5 ms. While λ(6-85) D14A has no significant slow phase, two even more stable mutants do. A slow phase of λ(6-85) D14A does appear in mild denaturant. The experimental data and computational modeling together suggest the following hypothesis: λ(6-85) takes only microseconds to reach its native state from an extensively unfolded state, while the latter takes milliseconds to reach compact β-rich traps. λ(6-85) is not only thermodynamically but also kinetically protected from reaching such "intramolecular amyloids" while folding.
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