ArticleMolecular vision2011
CFH 184G as a genetic risk marker for anterior uveitis in Chinese females.
Article in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- An updated advancement of bifunctional IL-27 in inflammatory autoimmune diseases.Frontiers in immunology · 2024Review
- Clinical Characteristics of Posner-Schlossman Syndrome Patients in China.BioMed research international · 2023Article
- Progress in the genetics of uveitis.Genes and immunity · 2022Review
- Article
- KIAA1109 gene mutation in surviving patients with Alkuraya-Kučinskas syndrome: a review of literature.BMC medical genetics · 2020Review
- Lack of association of C3 gene with uveitis: additional insights into the genetic profile of uveitis regarding complement pathway genes.Scientific reports · 2017Article
- Targeting the complement system for the management of retinal inflammatory and degenerative diseases.European journal of pharmacology · 2016Review
- Genetic of uveitis.International ophthalmology · 2016Review
- Association of the C2-CFB locus with non-infectious uveitis, specifically predisposed to Vogt-Koyanagi-Harada disease.Immunologic research · 2016Article
- Genetic dissection of acute anterior uveitis reveals similarities and differences in associations observed with ankylosing spondylitis.Arthritis & rheumatology (Hoboken, N.J.) · 2015Article
- Gender specific association of a complement component 3 polymorphism with polypoidal choroidal vasculopathy.Scientific reports · 2014Article
- Plasma metabonomics study of the patients with acute anterior uveitis based on ultra-performance liquid chromatography-mass spectrometry.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014Article
- Influence of molecular genetics in Vogt-Koyanagi-Harada disease.Journal of ophthalmic inflammation and infection · 2014Review
- Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis.Molecular vision · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association of three single nucleotide polymorphisms (SNPs) in the complement factor H (CFH), KIAA1109, and interleukin-27 (IL-27) genes in patients with anterior uveitis (AU).
methodsA case-control study was performed in 98 Chinese AU patients and 308 healthy controls. Three SNPs including CFH-rs800292, KIAA1109-rs4505848, and IL27-rs4788084 were detected using TaqMan SNP Genotyping Assays. Analyses were also stratified according to gender, clinical features and human leukocyte antigen (HLA)-B27 status of the patients.
resultsNo significant association was found between all three SNPs and AU. However, when stratified by gender, there were significant increases in the frequency of the CFH-rs800292 184G allele and GG homozygosity in female patients compared with control subjects (p=0.003 and p=0.009, respectively). Similar association was not detected in males. No significant association was found between AU and KIAA1109-rs4505848 or IL27-rs4788084 even stratified by gender. There was no significant difference in genotypes of AU patients stratified by various clinical features. Subgroup analyses showed that all three SNPs (rs800292, rs4505848, and rs4788084) were not associated with AU in HLA-B27-positive patients, neither in HLA-B27-negative patients.
conclusionsOur results showed an association between AU and CFH polymorphism in Chinese female patients but not in males, indicating gender-specific genetic differences in CFH. Gender should be considered in genetic studies of anterior uveitis even extending to other immunologic diseases.
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Identifiers
22065918PMC3209418W1861276470What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.