ArticleDento maxillo facial radiology2011
Fractal dimension evaluation of cone beam computed tomography in patients with bisphosphonate-associated osteonecrosis.
Article in Dento maxillo facial radiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Use of fractal analysis in dental images: a systematic review.Dento maxillo facial radiology · 2020Pooled it
- Capability of CBCT to identify patients with low bone mineral density: a systematic review.Dento maxillo facial radiology · 2017Pooled it
- Quantitative Bone Assessment in Medication-Related Osteonecrosis of the Jaw Using Fractal Analysis: A Systematic Review of the Literature and Clinical Perspectives.Dentistry journal · 2026Review
- Comparison of fractal analysis in panoramic radiography and panoramic reconstructions obtained by cone beam computed tomography.Oral radiology · 2026Article
- Evaluation of trabecular architecture and bone density in periradicular bone of dilacerated mandibular third molars: a cone beam computed tomography study.BMC medical imaging · 2026Article
- Relationship between maxillary sinus volume and alveolar trabeculation at orthodontic mini-implant sites across vertical skeletal patterns: a cross-sectional CBCT analysis.BMC medical imaging · 2025Article
- Bone-formation-related markers in osteonecrosis of the jaws and their correlation with radiographic findings.Oral and maxillofacial surgery · 2025Article
- A retrospective comparative fractal and radiomorphometric analysis of the effect of bisphosphonate use pattern and duration on the mandible.Oral radiology · 2025Article
- Fractal Dimension Analysis of Mandibular Trabecular Bone in Patients Receiving Antiresorptive Therapy for Osteoporosis and Oncologic Conditions.Diagnostics (Basel, Switzerland) · 2025Article
- Comparison of quantitative radiomorphometric predictors of healthy and MRONJ-affected bone using panoramic radiography and cone-beam CT.Dento maxillo facial radiology · 2024Article
- Efficacy of the CALMDentistry journal · 2024Article
- Evaluation of the mandibular condyles trabecular structure in patients with severe class III pattern: a computed tomography (CT) fractal analysis study.Scientific reports · 2023Article
- Fractal dimension analysis on CBCT scans for detecting low bone mineral density in postmenopausal women.Imaging science in dentistry · 2022Article
- Evaluation of trabecular bone healing using fractal dimension analysis after augmentation of alveolar crests with autogenous bone grafts: a preliminary study.Oral radiology · 2022Article
- A Comparison of the Clinical and Radiological Extent of Denosumab (XgevaJournal of clinical medicine · 2021Article
- Several issues regarding the diagnostic imaging of medication-related osteonecrosis of the jaw.Imaging science in dentistry · 2020Review
- Effect of multiple injections of botulinum toxin into painful masticatory muscles on bone density in the temporomandibular complex.Journal of oral rehabilitation · 2020Article
- Imaginological characterization of multiple myeloma lesions of the jaws through cone-beam computed tomography.Oral radiology · 2020Observational
- Tomographic study of Jaw bone changes in patients with bisphosphonate-related osteonecrosis.Journal of clinical and experimental dentistry · 2020Article
- Bisphophonate alterations of the jaw bones in individuals with multiple myeloma.Dento maxillo facial radiology · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
objectivesThe aim of this study was to (1) evaluate the fractal dimension (FD) in regions of the mandible on cone beam CT (CBCT) images of patients with bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) and (2) to select the most suitable region of interest (ROI) for further study on detection of bone alterations associated with bisphosphonates.
methodsCBCT images of patients with BP-ONJ were included with matched controls. Values of FD were compared between groups. Selected ROIs were: ROI-1 - below the mandibular foramen; ROI-2 - above the mandibular foramen; ROI-3 - anterior to the mental foramen; ROI-4 - above the mandibular canal. The area of bone exposure was included as ROI-5. The results were analysed using generalized estimating equations and conditional logistic regression.
resultsThere were 36 patients (67% female) with a mean age of 60.7 years. The mean FDs were: ROI-1 - 1.678 for controls and 1.673 for patients (P = 0.81); ROI-2 - 1.657 for controls and 1.653 for patients (P = 0.78); ROI-3 - 1.661 for controls and 1.684 for patients (P = 0.17); and ROI-4 - 1.670 for controls and 1.698 for patients (P = 0.03). The value of the FD in the area of exposed bone was the highest (1.729). The odds of being a BP-ONJ patient vs being a control was six times as high for individuals with a higher FD score at ROI-4, although the confidence interval was quite wide owing to the small sample size.
conclusionIn this preliminary study, BP-ONJ patients had higher FD values than controls at regions close to the alveolar process. The results suggest that FD is a promising tool for detection of bone alterations associated with BP-ONJ.
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