ArticleProceedings of the National Academy of Sciences of the United States of America2011
Competition is a driving force in topographic mapping.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Teneurin-3 and latrophilin-2 are required for somatotopic map development and somatosensory topognosis.Current biology : CB · 2026Article
- Connectivity, Computation, and Plasticity of the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Teneurin-3 and latrophilin-2 are required for somatotopic map formation and somatosensory topognosis.bioRxiv : the preprint server for biology · 2025Article
- Article
- Complex computation from developmental priors.Nature communications · 2023Article
- Activity-dependent Organization of Topographic Neural Circuits.Neuroscience · 2023Review
- Segregation of Multimodal Inputs Into Discrete Midbrain Compartments During an Early Critical Period.Frontiers in neural circuits · 2022Article
- Atoh7-independent specification of retinal ganglion cell identity.Science advances · 2021Article
- Wiring subcortical image-forming centers: Topography, laminar targeting, and map alignment.Current topics in developmental biology · 2021Review
- New insights on the modeling of the molecular mechanisms underlying neural maps alignment in the midbrain.eLife · 2020Article
- Trans-Axonal Signaling in Neural Circuit Wiring.International journal of molecular sciences · 2020Review
- Molecular complexity of visual mapping: a challenge for regenerating therapy.Neural regeneration research · 2020Review
- Network cloning using DNA barcodes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A stochastic framework to model axon interactions within growing neuronal populations.PLoS computational biology · 2018Article
- Theoretical Models of Neural Development.iScience · 2018Review
- Developmental interactions between thalamus and cortex: a true love reciprocal story.Current opinion in neurobiology · 2018Review
- Visual subcircuit-specific dysfunction and input-specific mispatterning in the superior colliculus of fragile X mice.Journal of neurodevelopmental disorders · 2018Article
- Article
- Novel Models of Visual Topographic Map Alignment in the Superior Colliculus.PLoS computational biology · 2016Article
- Quantitative Analysis of Axonal Branch Dynamics in the Developing Nervous System.PLoS computational biology · 2016Article
Corrections and comments
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9 authors.
Funding
Abstract
Topographic maps are the primary means of relaying spatial information in the brain. Understanding the mechanisms by which they form has been a goal of experimental and theoretical neuroscientists for decades. The projection of the retina to the superior colliculus (SC)/tectum has been an important model used to show that graded molecular cues and patterned retinal activity are required for topographic map formation. Additionally, interaxon competition has been suggested to play a role in topographic map formation; however, this view has been recently challenged. Here we present experimental and computational evidence demonstrating that interaxon competition for target space is necessary to establish topography. To test this hypothesis experimentally, we determined the nature of the retinocollicular projection in Math5 (Atoh7) mutant mice, which have severely reduced numbers of retinal ganglion cell inputs into the SC. We find that in these mice, retinal axons project to the anteromedialj portion of the SC where repulsion from ephrin-A ligands is minimized and where their attraction to the midline is maximized. This observation is consistent with the chemoaffinity model that relies on axon-axon competition as a mapping mechanism. We conclude that chemical labels plus neural activity cannot alone specify the retinocollicular projection; instead axon-axon competition is necessary to create a map. Finally, we present a mathematical model for topographic mapping that incorporates molecular labels, neural activity, and axon competition.
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