ArticleThe Journal of biological chemistry2011
Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Alternative isoform expression of key thermogenic genes in human beige adipocytes.Frontiers in endocrinology · 2024Article
- Therapeutic RNA-silencing oligonucleotides in metabolic diseases.Nature reviews. Drug discovery · 2022Review
- Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone α.Molecular and cellular biology · 2022Article
- The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis.Nature communications · 2021Article
- Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health.Cell & bioscience · 2021Review
- Specific ablation of the NCoR corepressor δ splice variant reveals alternative RNA splicing as a key regulator of hepatic metabolism.PloS one · 2020Article
- Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals.BMC research notes · 2019Article
- Alternative mRNA Splicing in the Pathogenesis of Obesity.International journal of molecular sciences · 2018Review
- RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs.The Journal of clinical investigation · 2017Article
- Corepressor diversification by alternative mRNA splicing is species specific.BMC evolutionary biology · 2016Article
- Pan-cancer analyses of the nuclear receptor superfamily.Nuclear receptor research · 2015Article
- Control of developmentally primed erythroid genes by combinatorial co-repressor actions.Nature communications · 2015Article
- Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling.Molecular and cellular endocrinology · 2015Article
- Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity.Nucleic acids research · 2015Article
- Short linear motif acquisition, exon formation and alternative splicing determine a pathway to diversity for NCoR-family co-repressors.Open biology · 2015Article
- Alteration of NCoR corepressor splicing in mice causes increased body weight and hepatosteatosis without glucose intolerance.Molecular and cellular biology · 2014Article
- The adipogenic transcriptional cofactor ZNF638 interacts with splicing regulators and influences alternative splicing.Journal of lipid research · 2014Article
- SRSF10 regulates alternative splicing and is required for adipocyte differentiation.Molecular and cellular biology · 2014Article
- Thyroid hormone signaling in energy homeostasis and energy metabolism.Annals of the New York Academy of Sciences · 2014Review
- Thyroid hormone regulation of metabolism.Physiological reviews · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The SMRT and NCoR corepressors partner with, and help mediate repression by, a wide variety of nuclear receptors and non-receptor transcription factors. Both SMRT and NCoR are expressed by alternative mRNA splicing, resulting in the production of a series of interrelated corepressor variants that differ in their tissue distribution and in their biochemical properties. We report here that different corepressor splice variants can exert opposing transcriptional and biological effects during adipocyte differentiation. Most notably, the NCoRω splice variant inhibits, whereas the NCoRδ splice variant promotes, adipogenesis. Furthermore, the ratio of NCoRω to NCoRδ decreases during adipogenic differentiation. We propose that this alteration in corepressor splicing helps convert the cellular transcriptional program from one that maintains the pre-adipocyte in an undifferentiated state to a new transcriptional context that promotes differentiation and helps establish the proper physiology of the mature adipocyte.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.