Evidence map›Paper›PMID 22065531›Full record

ArticleArchives of general psychiatry2011

Personality disorders and the 3-year course of alcohol, drug, and nicotine use disorders.

Deborah Hasin, Miriam C Fenton, Andrew Skodol, Robert Krueger, Katherine Keyes, Timothy Geier, Eliana Greenstein, Carlos Blanco, Bridget Grant

Open access · bronzeAbstract read
In one paragraph

Article in Archives of general psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 200 citations in OpenAlex.

  1. Trial
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  9. Female Psychopathy and Mortality.Frontiers in psychiatry · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. GRM8 genotype is associated with externalizing disorders and greater inter-trial variability in brain activation during a response inhibition task.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020
    Article
  14. Article
  15. Article
  16. Review
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  18. Clinical features associated with an increased risk for alcohol use disorders among family members.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2018
    Article
  19. Article
  20. Testing Genetic and Environmental Associations Between Personality Disorders and Cocaine Use: A Population-Based Twin Study.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2018
    Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Deborah HasinDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, NY 10032, USA. dsh2@columbia.edu
Miriam C Fenton
Andrew Skodol
Robert Krueger
Katherine Keyes
Timothy Geier
Eliana Greenstein
Carlos Blanco
Bridget Grant
Columbia University · US

Funding

Phenotypes for Drug Abuse:Epidemiologic-Genetic ApproachR01DA018652 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HASIN, DEBORAH S · 2004 to 2018
$5.3M
Adverse childhood experiences, personality psychopathology, and alcohol disordersU01AA018111 · NIAAA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HASIN, DEBORAH S · 2009 to 2013
$3.4M
Towards a Comprehensive Developmental Model of Substance Use DisordersR01DA019606 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI OLFSON, MARK · 2006 to 2016
$2.6M
Epidemiologic Studies of Alcohol Use Disorders (ongoing)K05AA014223 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HASIN, DEBORAH S · 2003 to 2012
$1.5M
Bridging Efficacy and Effectiveness in Drug Abuse TreatmentK02DA023200 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANCO, CARLOS · 2008 to 2012
$618k
Age-period-cohort effects on substance use in adolescence, 1976-2006F31DA026689 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KEYES, KATHERINE M. · 2009 to 2009
$25k
NIAAA NIH HHS K05 AA014223NIAAA NIH HHS U01 AA018111NIDA NIH HHS F31 DA026689NIDA NIH HHS K02 DA023200NIDA NIH HHS R01 DA018652NIDA NIH HHS R01 DA019606
6 · The paper itself

Abstract

contextLittle is known about the role of a broad range of personality disorders in the course of substance use disorder (SUD) and whether these differ by substance. The existing literature focuses mostly on antisocial personality disorder and does not come to clear conclusions.

objectiveTo determine the association between the 10 DSM-IV personality disorders and the persistence of common SUDs in a 3-year prospective study of a national sample.

designData were drawn from participants in the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) who had alcohol dependence (n = 1172), cannabis use disorder (n = 454), or nicotine dependence (n = 4017) at baseline and who were reinterviewed 3 years later. Control variables included demographic characteristics, family history of substance disorders, baseline Axis I disorders and treatment status, and prior SUD duration. Main Outcome Measure  Persistent SUD, defined as meeting full criteria for the relevant SUD throughout the 3-year follow-up period.

resultsPersistent SUD was found among 30.1% of participants with alcohol dependence, 30.8% with cannabis use disorder, and 56.6% with nicotine dependence at baseline. Axis I disorders did not have strong or consistent associations with persistent SUD. In contrast, antisocial personality disorder was significantly associated with persistent alcohol, cannabis, and nicotine use disorders (adjusted odds ratios, 2.46-3.51), as was borderline personality disorder (adjusted odds ratios, 2.04-2.78) and schizotypal personality disorder (adjusted odds ratios, 1.65-5.90). Narcissistic, schizoid, and obsessive-compulsive personality disorders were less consistently associated with SUD persistence.

conclusionsThe consistent findings on the association of antisocial, borderline, and schizotypal personality disorders with persistent SUD indicates the importance of these personality disorders in understanding the course of SUD. Future studies should examine dimensional representations of personality disorders and the role of specific components of these disorders, biological and environmental contributors to these relationships, and potential applications of these findings to treatment development.

Indexed as

AdolescentAdultAlcoholismComorbidityDemographyDiagnostic and Statistical Manual of Mental DisordersFemaleHealth SurveysHumansMaleMarijuana AbuseMiddle AgedPersonality DisordersPrevalencePsychiatric Status Rating ScalesRisk Assessment

Identifiers

PMID22065531
PMCPMC3500879
OpenAlexW2133098680

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.