ArticleJournal of the American Society for Mass Spectrometry2012
Pathways for water loss from doubly protonated peptides containing serine or threonine.
Article in Journal of the American Society for Mass Spectrometry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Exploring Field-Induced Fragmentation of Protonated Alcohols: Mechanistic Insights and Stabilizing Ion-Solvent Clusters.Journal of the American Society for Mass Spectrometry · 2026Article
- Dehydroamino acids and their crosslinks in Alzheimer's disease aggregates.Brain communications · 2025Article
- Water Loss from Protonated XxxSer and XxxThr Dipeptides Gives Oxazoline-Not Oxazolone-Product Ions.Journal of the American Society for Mass Spectrometry · 2020Article
- Large-Scale Examination of Factors Influencing Phosphopeptide Neutral Loss during Collision Induced Dissociation.Journal of the American Society for Mass Spectrometry · 2015Article
- Protonated dipeptide losses from b(5) and b(4) ions of side chain hydroxyl group containing pentapeptides.Journal of the American Society for Mass Spectrometry · 2013Article
- Gas phase chemistry of Li+ with amides: the observation of LiOH loss in mass spectrometry.Journal of the American Society for Mass Spectrometry · 2012Article
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Authors and funding
1 author.
Funding
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Abstract
The doubly-protonated peptides Ala-Ala-Xaa-Ala-Ala-Ala-Arg show extensive loss of H(2)O when Xaa = Ser or Thr. Using quasi-MS(3) techniques the fragmentation reactions of the [M + 2H - H(2)O](+2) ions have been studied in detail. For both Ser and Thr, the [M + 2H - H(2)O](+2) ions show three primary fragmentation reactions, elimination of CH(3)CH=NH, elimination of one Ala residue, and elimination of two Ala residues, in all cases forming doubly-charged products. From a study of the further fragmentation of these products, it is concluded that elimination of two Ala residues results in formation of a three-membered aziridine ring by interaction with the adjacent amide function as H(2)O is lost. The elimination of one Ala residue results in formation of a five-membered oxazoline ring through interaction with the N-terminal adjacent carbonyl function as H(2)O is lost. The elimination of CH(3)CH=NH appears to involve formation of an eight-membered ring by interaction with the remote N-terminal carbonyl function as H(2)O is lost. However, this initial structure undergoes rearrangement through interaction with the adjacent C-terminal carbonyl function prior to further fragmentation. The [MH - H(2)O](+) ion of Ala-Ala-Ser-Ala-Ala-Ala also shows elimination of CH(3)CH=NH, one Ala residue and two Ala residues.
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Registered trials
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