ArticleCell research2011
An atypical component of RNA-directed DNA methylation machinery has both DNA methylation-dependent and -independent roles in locus-specific transcriptional gene silencing.
Article in Cell research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes.Nature cell biology · 2025Article
- DNA-dependent RNA polymerases in plants.The Plant cell · 2023Article
- Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family.Nature genetics · 2018Article
- Exploring potential roles for the interaction of MOM1 with SUMO and the SUMO E3 ligase-like protein PIAL2 in transcriptional silencing.PloS one · 2018Article
- The developmental regulator PKL is required to maintain correct DNA methylation patterns at RNA-directed DNA methylation loci.Genome biology · 2017Article
- Alternative Splicing in Plant Genes: A Means of Regulating the Environmental Fitness of Plants.International journal of molecular sciences · 2017Review
- Two Components of the RNA-Directed DNA Methylation Pathway Associate with MORC6 and Silence Loci Targeted by MORC6 in Arabidopsis.PLoS genetics · 2016Article
- Two domain-disrupted hda6 alleles have opposite epigenetic effects on transgenes and some endogenous targets.Scientific reports · 2015Article
- RNA Pol IV and V in gene silencing: Rebel polymerases evolving away from Pol II's rules.Current opinion in plant biology · 2015Review
- DNA methylation pathways and their crosstalk with histone methylation.Nature reviews. Molecular cell biology · 2015Review
- siRNA-directed DNA Methylation in Plants.Current genomics · 2015Article
- SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis.Cell research · 2014Article
- Connecting the dots of RNA-directed DNA methylation in Arabidopsis thaliana.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Review
- RNA Splicing Factors and RNA-Directed DNA Methylation.Biology · 2014Article
- The SET domain proteins SUVH2 and SUVH9 are required for Pol V occupancy at RNA-directed DNA methylation loci.PLoS genetics · 2014Article
- RNA-directed DNA methylation in plants: Where to start?RNA biology · 2013Review
- Folate polyglutamylation is involved in chromatin silencing by maintaining global DNA methylation and histone H3K9 dimethylation in Arabidopsis.The Plant cell · 2013Article
- Article
- DTF1 is a core component of RNA-directed DNA methylation and may assist in the recruitment of Pol IV.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The splicing machinery promotes RNA-directed DNA methylation and transcriptional silencing in Arabidopsis.The EMBO journal · 2013Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
RNA-directed DNA methylation (RdDM) is an important de novo DNA methylation pathway in plants. RdDM mediates the transcriptional silencing of many endogenous genomic loci, most of which are transposon related. A forward genetics screen identified DTF1 (DNA-binding transcription factor 1) as a new component for RdDM in Arabidopsis. Loss-of-function mutations in DTF1 release the transcriptional silencing of RdDM target loci and reduce the accumulation of 24-nt small interfering RNAs (siRNAs) from some of the targets. Interestingly, in the dtf1 mutant plants, the release of transcriptional gene silencing at solo-LTR is accompanied by decreased siRNA accumulation but not by reduced DNA methylation. These results suggest that DTF1 is an atypical component of RdDM and has both DNA methylation-dependent and -independent roles in transcriptional gene silencing. We suggest that besides DNA methylation, siRNAs may cause some other uncharacterized epigenetic modifications that lead to transcriptional gene silencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.