ReviewOrganogenesis
Cell polarity: The missing link in skeletal morphogenesis?
Review in Organogenesis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Clarifying Frizzled 2 function in development through genetically validated mouse models.Disease models & mechanisms · 2026Article
- Article
- Bone fracture healing: perspectives according to molecular basis.Journal of bone and mineral metabolism · 2021Review
- Mechanical stimulation of growth plate chondrocytes: Previous approaches and future directions.Experimental mechanics · 2019Article
- Mechanical loading regulates organization of the actin cytoskeleton and column formation in postnatal growth plate.Molecular biology of the cell · 2017Article
- A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation.Frontiers in cell and developmental biology · 2017Article
- Dchs1-Fat4 regulation of polarized cell behaviours during skeletal morphogenesis.Nature communications · 2016Article
- Regulation of Long Bone Growth in Vertebrates; It Is Time to Catch Up.Endocrine reviews · 2015Review
- Planar cell polarity aligns osteoblast division in response to substrate strain.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Advances in Skeletal Dysplasia Genetics.Annual review of genomics and human genetics · 2015Review
- A dynamic cell adhesion surface regulates tissue architecture in growth plate cartilage.Development (Cambridge, England) · 2014Article
- Induction of WNT inhibitory factor 1 expression by Müllerian inhibiting substance/antiMullerian hormone in the Müllerian duct mesenchyme is linked to Müllerian duct regression.Developmental biology · 2014Article
- Cartilage to bone transitions in health and disease.The Journal of endocrinology · 2013Review
- Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate development.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Despite extensive genetic analysis of the dynamic multi-phase process that transforms a small population of lateral plate mesoderm into the mature limb skeleton, the mechanisms by which signaling pathways regulate cellular behaviors to generate morphogenetic forces are not known. Recently, a series of papers have offered the intriguing possibility that regulated cell polarity fine-tunes the morphogenetic process via orienting cell axes, division planes and cell movements. Wnt5a-mediated non-canonical signaling, which may include planar cell polarity, has emerged as a common thread in the otherwise distinct signaling networks that regulate morphogenesis in each phase of limb development. These findings position the limb as a key model to elucidate how global tissue patterning pathways direct local differences in cell behavior that, in turn, generate growth and form.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.